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We are interested in mechanisms by which endocrine hormones influence the immune response. Receptors for steroid hormones (estrogens, androgens, and progesterone) are broadly expressed and regulate gene transcription in target cells. We study how these pathways operate in immune cells, particularly how they contribute to the balance between immune homeostasis and chronic inflammation & autoimmunity.

Wendy A. Goodman's Biography 

The massively complex human genome is a super-computer that carefully controls its information. It uses chemical-genetic circuits, 3D folding, and signal integration to maintain cell identity and all biological functions. Our lab is excited to unravel the principles of the super-computer we call the epigenome, and do so in the context of cancer.

Berkley Gryder's Biography

I research biomarkers for early detection and prognosis of prostate cancer, molecular targets for prevention and treatment of prostate cancer, and epigenetic mechanisms of gene silencing.

I focus on molecular mechanisms regulating antibody-mediated immunity to infections and B cell lymphoma pathogenesis.

My focus is on genetic epidemiology of neurological and opthalmological disorders, as well as computational methods for biomedical big data. 

Jonathan Haines's Biography 

Our laboratory is interested in the chronic infection- or inflammation-induced colorectal cancer (CRC), which can cause the majority of metastatic CRC (CRC) over time without intervention. One of the most important pathogeneses of mCRC is cancer stem cell (CSC) malignancy induced by somatic mutations. Using murine and human adult stem cell- and human induced pluripotent stem cell (IPSC)-derived tumoroids, our laboratory comprehensively tests the genetic and epigenetic mechanisms of CSC malignancy during loss of anti-proinflammatory TH2 cytokine-JAKs-STAT5 signaling, further determine the targets of intervention of CSC-induced mCRC.

Xiaonan Han's Biography 

1. Regulation of respiration and blood gas homeostasis. In vivo studies in small and large mammals, neural mechanisms of control of respiration
2. toxicology: Development of countermeasures against mitochondrial poisons
3. Opioid overdose

My areas of research include immunology, MHC, antigen processing, T cell, phagocytosis, endocytosis, subcellular fractionation, mycobacteria, tumor immunity, tuberculosis, cell biology, exosomes, and extracellular vesicles. 

Clifford V. Harding's Biography 

I research tissue-specific and temporal regulation of gene expression in health and disease. In addition, I study functional genomics of regulatory elements, transcriptional networks, and Chromatin architecture.

Ann Harris's Biography

My focus is in transcription activation, repression, Chromatin structure, and homeotic genes.

Peter J. Harte's Biography