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We study the mechanisms of acquired immunity to malaria, SARS-CoV-2 and filariasis with a focus on humoral immunity.  This work involves B cell molecular immunology and development human monoclonal antibodies as therapies.  We also develop novel tools for control and elimination of lymphatic filariasis and onchocerciasis.

Christopher L. King's Biography 

My lab utilizes mouse models and other approaches to study animal and human prion diseases, especially on zoonosis of animal prions (such as mad cow disease in cattle and chronic wasting disease in deer, elk and moose) and modeling, diagnosis and pathogenesis of various prion diseases.  We also are developing gene and cell therapies for neurodegenerative diseases (such as prion diseases and Alzheimer's disease), cancer and diabetes. 

Qingzhong Kong's Biography 

I analyze high-throughput biological data, algorithmic and analytical methods in systems/network biology, algorithms for data mining and analysis, parallel computing, algorithms for distributed systems, and optimization problems in scientific computing.

I research self-propagating misfolded proteins of neurodegenerative diseases, including Alzheimer’s, chronic traumatic encephalopathy, Parkinson’s, and prion diseases. I also focus on the analysis of what makes a misfolded protein transmissible, and what makes a transmissible protein seed pathogenic to the host. 

Allison Kraus's Biography

We develop and apply computational tools to identify molecular variants that contribute to cancer and related diseases in humans. 

The Langel lab is focused on understanding antibody and B cell responses to viral infections, particularly during pregnancy and lactation. To accomplish this, the Langel lab is using single cell technologies, translational animal models, and human clinical samples. The Langel lab's overall goal is to improve maternal and neonatal health around the world.

Stephanie Langel's Biography 

We use in vivo imaging models to interrogate the tumor microenvironment, examining communication mechanisms in cancer stem cells, currently focused on malignant brain tumors.

I focus on TGF-ß in immune cell development and function, as well as tumor suppressor functions of TGF-b.

John J. Letterio's Biography 

My research includes intestinal host defense: immune tolerance and immune protection in inflammatory bowel disease, HIV or SARS-CoV-2 infection, and opioid use disorder.

Alan Levine's Biography

Our human microbiota consists of complex communities where microbial interactions modulate bacterial behavior and influence human health. The Lewin lab is interested in understanding the role of microbial interactions in polymicrobial sites, especially the oral microbiome. We use cutting-edge computational techniques and wet-lab approaches to study these interactions in the context microbial diversity and the dynamic infection environment.

Gina Lewin's Biography