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I study RNA systems biology in precision medicine.

Xiao Li's Biography 

I investigate single cell genomics in diabetes research, non-coding cis-regulatory elements in development and complex diseases, and functional characterization of non-coding GWAS SNPs in diabetic conditions.

Yan Li's biography

My research includes signal transduction in innate and adaptive immunity. 

Xiaoxia Li's Biography 

My lab is interested in understanding how the immune system responds to a variety of insults (e.g. bacteria, viruses, tumors) to control human diseases (e.g. infectious diseases and cancer). Increasing evidence has implicated that metabolism plays a crucial role in shaping immune cell phenotype and function. Our studies aim to investigate the interactions between metabolism and innate immune response in the settings of lung infection and cancer.

Xin Liu's Biography

We are interested in data mining of cancer genomes using computer programming and statistical modeling, aiming to understand cancer etiology and identify cancer vulnerabilities accordingly.

Yang Liu's Biography 

My research focuses on the investigations on the role of genetic factors and mitochondria-associated mechanisms in neurodegenerative diseases including Alzheimer’s Disease (AD), Frontotemporal dementia (FTD), and Amyotrophic lateral sclerosis (ALS) using both dry and wet lab multiple approaches. Our goal is to understand mechanistic insights into genetic variants causing the pathogenesis of diseases and to develop translational therapeutic strategies for neurodegenerative disorders.

Tian Liu's Biography 

We are interested in utilizing X-ray and electron microscopic technologies to study macromolecular complexes that underlie the activation of G protein-coupled receptors and G proteins. We also utilize Mass spectroscopy and other biophysical techniques to further understand the enzymology and kinetics of these processes. 

David T. Lodowski's Biography 

I am interested in alternative RNA processing and its role in health and disease, including correction of splicing mutations in diseases. 

Hua Lou's Biography

Our lab is interested in the role of the brain barriers (meninges, choroid plexus and blood brain barrier) in the context of neurodevelopmental and neurodegenerative diseases. Particularly, we are interested how the immune cells, vascular cells and stromal cells interact with each other to modulate glial and neuronal function. We use a combination of imaging (macroscopic, confocal, in vivo), flow cytometry (regular and spectral), in vivo intervention (surgeries, pharmacological and genetic) and behavior in mouse models of Autism spectrum disorders and Alzheimer's disease. Our approaches aim at developing new and unconventional therapeutic targets for these disorders.

Our lab explores topics at the interface between molecular virology and the systems-level host response to RNA virus infections, with a special emphasis on RNA driven processes. Incorporating classic virology approaches with innovative sequencing and imaging methods, our approach emphasizes the investigation of host-pathogen interactions in a diverse array of disease-relevant contexts, from COVID-19 to cancer.

Joseph Luna's Biography