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I research the role of gut microbiome in cardiometaboilc diseases and oxidative pathways in inflammation and cardiovascular disease.

The research performed in the Hine lab is focused on nutritional, environmental, and genetic factors impacting aging and longevity. To this end, we use in vivo, cellular, and in vitro model systems to understand the hormonal and nutritional regulation of endogenous hydrogen sulfide (H2S) metabolism to cultivate clinically applicable interventions to harness endogenous H2S production for beneficial health outcomes such as increased stress resistance, metabolic fitness, cognition, and lifespan.

Christopher Hine's Biography

I investigate correction of disease manifestations of Cystic Fibrosis, the creation of mouse models, and modifier genes. 

Craig Hodges's Biography 

My lab investigates interactions of intestinal epithelia and the surrounding microenvironment in promoting progression to cancer; colitis-derived tumor initiating cells, induced pluripotent stem cells. 

I research the regulation between immune activation and tolerance in the pathogenesis of cancer, and intravital 2-photon laser scanning microscopy to study various aspects of in vivo immunity and pathogenesis. 

Alex Y.C. Huang's Biography 

I research molecular and statistical genetic dissection of multifactorial diseases; common chronic diseases of the eye and the kidney; speech sound disorder. 

Sudha K. Iyengar's Biography 

My area of investigation includes tumor microenvironment, tumor immunology, mestastasis, and cellular transformation.

Mark Jackson's Biography

My areas of research include signaling complexes of rhodopsin, rhodopsin oligomeric organization in signal transduction, Molecular bases of light-induced retinal degeneration, and mouse models of retinal degenerative diseases.

Beata Jastrzebska's Biography 

I study molecular mechanisms and gene regulatory functions of 3D genome architecture, computational and system biology tools for integrative analysis of genomic data, and single cell transcriptome/epigenome technologies in health and disease. 

Fulai Jin's Biography 

We are investigating the effect of exosomes, a group of extracellular vesicles (EVs), from virus infected cells on cancer progression, inflammation and co-infection. We are utilizing the "EV-omics", including proteomics, RNAseq, lipidomics and metabolics to identify exosomes cargoes that contribute to diseases. We are also developing exosome therapeutic techniques in cancer treatment and regenerative medicine.