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Our lab is generally interested in how resident microbes in the gut interact with the host epithelium to promote homeostasis and how these interactions become altered in pathological states like inflammatory bowel disease. Specifically, we study how small molecules produced by microbes serve as metabolic precursors and receptor ligands, thereby influencing energy balance and gene expression in host cells.

Peder Lund's Biography

I research Eukaryotic gene transcription and RNA polymerase. 

My areas of investigation include hematology and pathophysiology of hematologic diseases including bone marrow failure syndromes (BMFS).

I research transcriptional regulation of inflammatory response.

I focus on signal transduction pathways that regulate normal cell growth and are disrupted by oncogenic mutations. In addition, I research molecular mechanisms underlying cancer chemo-preventative agents such as vitamin E.

Danny Manor's Biography

My research is primarily focused on the molecular biology of colon cancer, functional influence of oncogenes and suppressor genes on transformation, metastasis, and response to therapies. 

Sanford Markowitz's Biography 

I perform large-scale mutational experiments characterizing the impacts of protein coding variants on cell function, including infectious diseases and immunity.

Kenneth Matreyek's Biography

Research projects in the Matsuoka Lab aim to decode genetic programs controlling vascularization, vascular cell diversity, and barrier integrity in the central nervous system. We employ advanced genetic, imaging, and omics approaches to dissect these developmental mechanisms using the zebrafish in vivo model combined with human-derived endothelial cell culture in vitro. Our goal is to discover novel molecular targets from our basic science research and translate this knowledge into developing therapeutics that can repair vascular and neural abnormalities in neurological diseases. 

Ryota Matsuoka's Biography 

My research includes cell death regulation, mechanism of epigenetic aging, the biological significance of DNA methylation age determining the timing of death, and the development of cell death inhibiting small compounds.

Shigemi Matsuyama's Biography

My focus is in vascular function in health and disease; inflammation and thrombosis, antiphospholipid antibodies, and miRNA.