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I focus on basic and translational research in gut mucosal immunity, including IBD and colitis-associated cancer. I also research sex differences and impact of microbiome in IBD and basic cytokine biology, particularly of IL-1 family members. 

Theresa Pizarro's Biography 

I research altered mitochondrial quality control and metabolic dysregulation in neurodegenerative disease - Huntington's, Parkinson's and Alzheimer's diseases, and develop therapeutics for these diseases. 

I research molecular mechanisms of membrane remodeling, fission and fusion in synaptic vesicle endocytosis and mitochondrial dynamics.

I research the regulation of signal transduction in health and disease: autoimmune diabetes, inflammatory diseases and cancer.

Parameswaran Ramakrishnan's Biography 

Our lab uses bacterial genetics approaches to study the virulence of the bacterial pathogen Pseudomonas aeruginosa. In particular we focus on the type III secretion system, a molecular syringe that many Gram-negative bacteria use to directly inject proteins into host cells. We are both interested in studying how this exciting nanomachine works, and what the proteins that get injected do. 

I study the hormonal regulation of cellular magnesium homeostasis and transport in liver cells under physiological conditions and in pathological diseases including diabetes and alcoholism.

My work involves applying informatics and simulation modeling techniques to address population health problems, particularly in the area of cancer control/prevention and health disparities.

Johnie Rose's Biography

My areas of investigation include regulation of the length of telomere repeats and their role in cell physiology, genetic pathways controlling gene silencing and cell aging, and the biology and biochemistry of vitamin K in mammals.

My areas of research include protein misfolding, structure-function correlations, amyloid immunochemistry, age-related neurodegeneration, transgenic mice therapeutics, translational medicine, prion diseases, and Alzheimer’s disease. 

Jiri Safar's Biography 

Our lab studies germ cell development. We take advantage of the many genetic, molecular and cell biological tools available in Drosophila to define how sex is determined and maintained in female germ cells, and why errors in this process leads to infertility and germ cell tumors. 

Helen Salz's Biography