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I research molecular mechanisms of membrane remodeling, fission and fusion in synaptic vesicle endocytosis and mitochondrial dynamics.

I research the regulation of signal transduction in health and disease: autoimmune diabetes, inflammatory diseases and cancer.

Parameswaran Ramakrishnan's Biography 

Our lab uses bacterial genetics approaches to study the virulence of the bacterial pathogen Pseudomonas aeruginosa. In particular we focus on the type III secretion system, a molecular syringe that many Gram-negative bacteria use to directly inject proteins into host cells. We are both interested in studying how this exciting nanomachine works, and what the proteins that get injected do. 

I study the hormonal regulation of cellular magnesium homeostasis and transport in liver cells under physiological conditions and in pathological diseases including diabetes and alcoholism.

My work involves applying informatics and simulation modeling techniques to address population health problems, particularly in the area of cancer control/prevention and health disparities.

Johnie Rose's Biography

My areas of investigation include regulation of the length of telomere repeats and their role in cell physiology, genetic pathways controlling gene silencing and cell aging, and the biology and biochemistry of vitamin K in mammals.

My areas of research include protein misfolding, structure-function correlations, amyloid immunochemistry, age-related neurodegeneration, transgenic mice therapeutics, translational medicine, prion diseases, and Alzheimer’s disease. 

Jiri Safar's Biography 

Our lab studies germ cell development. We take advantage of the many genetic, molecular and cell biological tools available in Drosophila to define how sex is determined and maintained in female germ cells, and why errors in this process leads to infertility and germ cell tumors. 

Helen Salz's Biography 

The ability to move the body with skill and flexibility is a remarkable achievement of biological control, and the loss of this ability in disease or injury can be devastating. The neural circuits that control skilled movements are distributed broadly across the central nervous system and contain, in the mouse, tens of millions of functionally diverse neurons. Our central goals are to identify the principles governing the flow of neural activity across these large, distributed networks, to determine how these principles enable skilled motor control, and to discover how neural dynamics are altered in neurodegenerative diseases. To achieve these goals, we use high-density recording techniques to measure the activity of neural ensembles during natural movement, optogenetic approaches to manipulate this activity, and modern computational methods to extract models of the population dynamics from the resulting neurophysiological datasets.

Britton Sauerbrei's Biography 

I focus on the genetics of neurodevelopmental disorders and pediatric-onset neurodegeneration, including tissue-specific requirements of ubiquitously expressed proteins in development and disease.