The Small Molecule Drug Development Shared Resource (SR) optimizes robust assays in 384-well format and to screen large chemical libraries to identify new small molecules for innovative cancer therapeutics.
Location
ÐÇ¿Õ´«Ã½ School of Medicine
Biomedical Research Building 747
2109 Adelbert Rd, Cleveland, OH 44106
Services
| Service/Expertise | Cost | Description |
|---|---|---|
| Initial consultation | None | Investigators receive feedback regarding assay development/HTS goals, while Director and Managing Director suggest optimal assay approaches |
| Training: Facility Orientation | None | 1-hr session covering all instruments |
| Training: Operetta microscope, or Cytation5 microscope |
$400 |
Two 2-hr sessions covering imaging, data storage and analysis |
| Operetta microscope, or Cytation5 microscope, hourly usage |
$30/hour |
Enables investigators to benefit from automated imaging including live cell systems |
| Image analysis on a remote server |
None |
Allows investigators to benefit from high throughput image analysis |
| Access to automated dispensers and washers |
None |
Provides investigators with access to high data density experimentation |
| Managing Director support | $100/hour | General support in assay development and execution |
| Bioactives Library access (3,200 cpds) | $400 |
Enables pilot screening, pathway elucidation and drugs repurposing |
| HTS Library access (100,000 molecules) |
$4,000 | Enables HTS and drug discovery |
| All-inclusive screening packages |
Quotes available |
Enables dedicated % effort from Managing Director, library access, and equipment time. Can include consumables and reagent costs. Priced on a per-project basis due to varying assay needs. |
Available Instruments
Synergy NEO2 plate reader ( Biotek/Agilent)
Operetta automated microscope (Perkin Elmer)
EL406 washer/dispenser (Biotek/Agilent)
MultiFLo dispenser (Biotek/Agilent)
Janus MDT liquid handling platform with 50nL 384 pin tool (Perkin Elmer, V&P Scientific)
Contact for More Information
Drew Adams, PhD, Director
216.368.4922
dja59@case.edu
Yuriy Fedorov, PhD, Managing Director
216.368.1506
yuriy.fedorov@case.edu