As the PRMC manager, Lydia oversees the daily activities of the Protocol Review and Monitoring System (PRMS) and supports the committee chairpersons of the Protocol Review and Monitoring Committee (PRMC) in ensuring that the committee carries out its scientific review functions efficiently and effectively. Lydia prepares meeting agendas and minutes, assigns reviewers, and sends PRMC approval letters. She assists clinical investigators with the development and submission of a complete protocol and consent form, ensuring that all the activation steps, including disease team signoff, are completed for all protocols. She also monitors approved studies to ensure that they maintain adequate patient accrual and scientific progress.