Derek Abbott graduated from the University of Virginia in 1993. He then matriculated to Vanderbilt University School of Medicine as an MSTP Student. While a graduate student, he studied the breast cancer genes BRCA1 and BRCA2, ultimately attaining a Ph.D. in Cell Biology. After completion of his medical school requirements, Dr. Abbott continued his clinical training in Anatomic Pathology at Brigham and Women's Hospital (Harvard Medical School) in Boston, MA. After completing his residency and board certification, Dr. Abbott joined the lab of Dr. Lewis Cantley in the Department of Systems biology at Harvard Medical School. While in Lew Cantley's lab, Dr. Abbott began deciphering the signal transduction cascade initiated by bacterial activation of the Crohn's Disease susceptibility protein, NOD2.
Dr. Abbott joined the ÐÇ¿Õ´«Ã½'s Department of Pathology in the fall of 2006. He is currently the Arline and Curtis F. Garvin Professor of Medicine, a Professor of Pathology and the co-director of the ÐÇ¿Õ´«Ã½ Medical Scientist Training Program. Current interests in the lab include genotype:phenotype correlations in inflammatory disease, drug development in genetic inflammatory disease and synthetic biology approaches to translational medicine. Outside of lab, he's quite busy keeping up with his wife, Dr. Kathryn Teng – Service Line Director and the Division Chief of General Internal Medicine at MetroHealth and his two children, Annabelle and Nate.
I focus on innate immunity, genetic and Inflammatory disease.
Research Information
Research Interests
The last decade has seen an explosion in our ability to understand the genetics of disease. While we are able to generate genetic data in disease quickly, an important bottleneck lies in the understanding of genetic mutations’ role in disease. My lab utilizes cutting-edge cell editing technology, synthetic biology and chemical biology to understand mutations role in disease and to better understand key genetic nodal points for translational innovation. This approach has led to the discovery of novel inhibitors of the inflammatory disease kinase, RIPK2, and more recently to novel mechanisms to inhibit the pyroptotic pore protein, Gasdermin D. Both of these pharmaceutical intervention show efficacy in inflammatory diseases as diverse as Inflammatory Bowel Disease, Psoriasis, Sarcoidosis and Sepsis.
Publications
Representative Publications (last 5 years):
Liu Z, Wang C, Yang J, Chen Y, Zhou B, Abbott DW, Xiao TS (2020). . Immunity. 2020 Jul 14;53(1):106-114.e5. doi: 10.1016/j.immuni.2020.06.007. Epub 2020 Jun 17. PMID: 32553275
Karmakar M, Minns M, Greenberg EN, Diaz-Aponte J, Pestonjamasp K, Johnson JL, Rathkey JK, Abbott DW, Wang K, Shao F, Catz SD, Dubyak GR, Pearlman E (2020). . Nat Commun. 2020 May 5;11(1):2212. doi: 10.1038/s41467-020-16043-9. PMID: 32371889. PMCID:
Rathkey JK, Xiao TS, Abbott DW (2020). J Biol Chem. 2020 Mar 6;295(10):3228-3238. doi: 10.1074/jbc.RA119.010604. Epub 2020 Jan 27. PMID: 31988247
Zammit NW, Siggs OM, Gray PE, Horikawa K, et al. (2019). . Nat Immunol. 2019 Oct;20(10):1299-1310. doi: 10.1038/s41590-019-0492-0. Epub 2019 Sep 18. PMID: 31534238
Liu Z, Wang C, Yang J, Zhou B, Yang R, Ramachandran R, Abbott DW, Xiao TS (2019). . Immunity. 2019 Jul 16;51(1):43-49.e4. doi: 10.1016/j.immuni.2019.04.017. Epub 2019 May 13. PMID: 31097341. PMCID:
Chirieleison, S.M., Rathkey, J.R. and D.W. Abbott*. (2018) . Sci Signal. 2018 Jul 17;11(539). pii: eaao3964. doi: 10.1126/scisignal.aao3964. *corresponding author
Yang, J., Liu, Z., Want, C., Yang, R., Rathkey, J.K. Shi, W., Dubyak, G.R., Abbott, D.W., and T.S. Xiao. (2018) . PNAS. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797. doi: 10.1073/pnas.1800562115. Epub 2018 Jun 11.
Liu, Z, Wang, C., Rathkey, J.K., Yang, J., Dubyak, G.R., Abbott, D.W. and T.S. Xiao. (2018). . Structure. 2018 May 1;26(5):778-784.e3. doi: 10.1016/j.str.2018.03.002. Epub 2018 Mar 22.
Dziedzic, S.A., Su, Z., Najafov, A., Amin, P., Pan, H., Sun, L., Zhu, H., Abbott, D.W. and J. Yuan. (2018). . Nat Cell Biol. 2018 Jan;20(1):58-68. doi: 10.1038/s41556-017-0003-1. Epub 2017 Dec 4.
Perez, J.M., Chen, Y. Xiao, T.S. and D.W. Abbott* (2018). . J Biol Chem. 2018 Jan 19;293(3):1100-1105. doi: 10.1074/jbc.RA117.000408. Epub 2017 Dec 6. *corresponding author
Rathkey, J.K., Benson, B.L, Chirieleison, S.M., Yang, J., Xiao, T.S., Dubyak, G.R., Huang, A.Y. and D.W. Abbott* (2017). . J Biol Chem. 2017 Sep 1;292(35):14649-14658. doi: 10.1074/jbc.M117.797217. Epub 2017 Jul 18. *corresponding author
Chirieleison, S.M., Marsh, R., Kumar, P., Rathkey, J.K., Dubyak, G.R. and D.W. Abbott* (2017). . J Biol Chem. 2017 Jun 9;292(23):9666-9679. doi: 10.1074/jbc.M117.781500. Epub 2017 Apr 12. *corresponding author
Chirieleison, S.M., Kertesy, S.B. and D.W. Abbott* (2016). . J Immunol. 2016 May 15;196(10):4291-7. doi: 10.4049/jimmunol.1502631. Epub 2016 Apr 4. *corresponding author
Petrosiute,A., Dorand, R.D., Nthale, J., Myers, J.T., Barkauskas, D.S., Chirieleison, S.M.,Pareek, T., Abbott, D.W., Stearns, D.S., Letterio, J.J., and A.Y. Huang. (2016). . Science. 2016 Jul 22;353(6297):399-403. doi: 10.1126/science.aae0477. Epub 2016 Jul 21.
Russo, H, Rathkey, J., Boyd-Tressler, A., Katsnelson, M.A., Abbott, D.W. and G.R. Dubyak. (2016). . Journal of Immunology, 197: 1353-67.
Perez, J.M., Chirieleison, S.M. and D.W. Abbott* (2015). . Cell Rep. 2015 Jul 28;12(4):537-44. doi: 10.1016/j.celrep.2015.06.050. Epub 2015 Jul 16. *corresponding author
Tigno-Aranjuez, J.T., Benderitter, P., Rombouts,F., Deroose, F., Bai, X., Mattioli, B., Cominelli, F., Pizarro, T.T., Hoflack, J., and D.W. Abbott* (2014). . J Biol Chem. 2014 Oct 24;289(43):29651-64. doi: 10.1074/jbc.M114.591388. Epub 2014 Sep 11. *corresponding author
Jun, J.C., Kertesy, S., Jones, M.B., Marinis, J.M., Cobb, B.A., Tigno-Aranjuez, J.T. and D.W. Abbott* (2013). . Cell Rep. 2013 Jul 25;4(2):352-61. doi: 10.1016/j.celrep.2013.06.036. Epub 2013 Jul 18. *corresponding author