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We study cellular immunology concentrating on chronic viral infections (HIV, HCV, SARS-CoV2) and inflammation in aging. We primarily study human blood cells and plasma to examine the effects of chronic inflammation on health, the mechanisms by which the immune system maintains homeostasis, and how inflammation disrupts the ability of the immune system to reestablish homeostasis after infection and during aging. We have extensive experience in immunological research in the fields of autoimmunity, T cell-specific adaptive immune responses, B-cell antibody responses, cytokines, innate immunity, inflammation, viral infection, and cellular biology. We use cell culture, ELISAs, ELISPOT assays, Cytokine and Antibody Multiplex assays (MSD, Luminex, ELLA), and flow cytometry to test our hypothesizes.

Carey Shive's Biography 

My areas of investigation include: HIV Immunology, antimicrobial peptides, head and neck cancer tumor microenvironment.

I research the role of glial cells in development and regeneration of neural circuits, nerve regeneration, glia, and axon guidance. 

Jerry Silver's Biography 

My focus is in molecular mechanisms of the antitumor and antiviral activities of interferons. 

My research includes prion diseases, protein transport, chaperones, proteasomes, and nuclear import. 

Neena Singh's Biography 

I research HIV-host cell interaction and accessory proteins.

Jacek Skowronski's Biography 

I research cell physiology, neural circuits and synaptic plasticity, systems neuroscience, neuroendocrinology, autonomic regulation, cardiovascular neuromodulation, and electrophysiology. 

I primarily research cholesterol metabolism by macrophages, the genetics of atherosclerosis susceptibility in mouse models, and genetics and drug discovery in mouse models of Alzheimer disease.

We communicate with our resident microbiota through the language of metabolites. Host-derived metabolites shape the balance between commensals and pathogens, and in turn, microbiota-derived metabolites tune host immune responses. This dialogue ultimately determines our susceptibility to disease. We use bacterial genetics, genomics, animal models, and immune profiling to decipher microbiota-host metabolic communication in the oral cavity, site of one of the most prevalent inflammatory diseases worldwide (periodontitis).

My primary research is in redox-based cellular regulation and signal transduction, and in particular the role of protein S-nitrosylation.