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The ability to move the body with skill and flexibility is a remarkable achievement of biological control, and the loss of this ability in disease or injury can be devastating. The neural circuits that control skilled movements are distributed broadly across the central nervous system and contain, in the mouse, tens of millions of functionally diverse neurons. Our central goals are to identify the principles governing the flow of neural activity across these large, distributed networks, to determine how these principles enable skilled motor control, and to discover how neural dynamics are altered in neurodegenerative diseases. To achieve these goals, we use high-density recording techniques to measure the activity of neural ensembles during natural movement, optogenetic approaches to manipulate this activity, and modern computational methods to extract models of the population dynamics from the resulting neurophysiological datasets.

Britton Sauerbrei's Biography 

I focus on the genetics of neurodevelopmental disorders and pediatric-onset neurodegeneration, including tissue-specific requirements of ubiquitously expressed proteins in development and disease.

We primarily utilize molecular and advanced imaging techniques in cells and mouse models to imterrogate pathophysiologic mechanisms of diabetes and diabetic kidney disease.

I focus on molecular mechanisms of breast cancer metastasis, metastatic dormancy, and metastastic relapse.

William P. Schiemann's Biography 

I research the molecular mechanisms of agonist-induced Ca2+ signaling in mammalian non-excitable cells: TRP family channels.

My primary research is in vascular biology of factor XII, kallikrein/kinin, renin-angiotensin, coagulation and complement systems, cancer and thrombosis, immunology of vascular thrombosis, tyrosine kinase inhibitors and vascular inflammation, ponatinib, malaria, COVID-19 pneumonia, and hereditary angioedema. 

Alvin H. Schmaier's Biography 

My research interests as a genetic epidemiologist focuses on three major areas - deciphering the genomic architecture of complex traits, assessing the shared genomic etiology of complex phenotypes to elucidate the underlying biology, and ascertaining the clinical impact of genomics. My research primarily focuses on cancer by utilizing computational tools. 

Fredrick Schumacher's Biography

Our lab studies cancer and pathogen evolution using theoretical models (mathematical/computational), experimental evolution (in vitro) and data science methods (-omics and AI/ML). 

Jacob Scott's Biography

I focus on mammalian gene expression of angiotensin-converting enzyme and interferon, in addition to the mechanism of interferon action. 

My research includes drug delivery and nanomedicine for treatment of hemostasis, thrombosis, inflammation, immune response and cancer metastasis. 

Anirban Sen Gupta's Biography