This 3D printed model of a protein recently solved by researchers is a visual aid for science communication and for more deeply understanding the way that the protein folds onto itself. This structure is the aggregated protein filament of TDP-43, which is related to neurodegenerative diseases like Amyotrophic lateral sclerosis (ALS). In patients, soluble proteins aggregate and form filaments like these which can cause neurotoxicity. Solving the structure can help researchers understand the disease mechanism and design related therapies.
Contact:
Qiuye Li, qxl112@case.edu