I research cell cycle regulation, acquired resistance to CDK4/6 inhibitors, ubiquitin-dependent protein degradation, unfolded Protein Response and Tumor Progression, Non-coding RNA, and the circadian clock.
Research Information
Research Interests
Dr. Diehl’s research focuses on the molecular mechanisms of cancer initiation and progression with specific focus on the regulation of cell division and post-translational in cancer. The Diehl lab also explores the interconnections of lipid signaling, epigenetic regulation and the role of the unfolded protein response within tumor progression.
One major focus of Dr. Diehl’s research concerns the mechanisms whereby growth-signaling pathways regulate the cyclin D/CDK4/6 kinases and from this, the identification of therapeutic vulnerabilities. His current work focuses on the role of E3 ubiquitin ligases in the maintenance of cyclin D1 levels and the physiological function of the E3 ligase in tumor suppression. Additional work focuses on the regulation of novel downstream substrates of the cyclin D1/CDK4 kinase and their role in mediating cyclin D1-dependent effects on tumor cell gene expression networks. A second area of interest concerns how a stress-induced signaling pathway emanating from the endoplasmic reticulum (ER) regulates cell cycle progression, lipid biosynthesis and cell survival during tumor progression.
Publications
- Yoshida, A, Choi, J., Jin, H., Li, Y., Bajpai, S., Qie, S. and Diehl, J. A.
Oncogene 40:292–306 (2021) - Yoshida A., Bu B., Qie S., Wrangle J., Cam E. R., Hazard E. S., Hardiman G., Leeuw R., Knudsen K. E., and Diehl J. A.
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Science Advances 5 (9): eaax6352 (2019). - Qie S., Yoshida A., Parnham S., Oleinik N., Beeson G. C., Beeson C. C., Ogretmen B., Bass A. J., Wong K. K., Rustgi A. K., and Diehl J. A.
Nat Commun 10 (1): 1296 (2019). - Qie S. and Diehl J. A.
Mol Cell Oncol 6 (4): 1610257 (2019). - Bu Y., Yoshida A., Chitnis N., Altman B. J., Tameire F., Oran A., Gennaro V., Armeson K. E., McMahon S. B., Wertheim G. B., Dang C. V., Ruggero D., Koumenis C., Fuchs S. Y., and Diehl J. A.
Nat Cell Biol 20 (1): 104-15 (2018). - Qie S., Majumder M., Mackiewicz K., Howley B. V., Peterson Y. K., Howe P. H., Palanisamy V., and Diehl J. A.
Nat Commun 8 (1): 1534 (2017). - Yoshida A., Lee E. K., and Diehl J. A.
Cancer Res 76 (10): 2990-3002 (2016). - Xu Z., Bu Y., Chitnis N., Koumenis C., Fuchs S. Y., and Diehl J. A.
Nat Commun 7: 11422 (2016). - Pytel D., Gao Y., Mackiewicz K., Katlinskaya Y. V., Staschke K. A., Paredes M. C., Yoshida A., Qie S., Zhang G., Chajewski O. S., Wu L., Majsterek I., Herlyn M., Fuchs S. Y., and Diehl J. A.
PLoS Genet 12 (12): e1006518 (2016). - Li Y., Chitnis N., Nakagawa H., Kita Y., Natsugoe S., Yang Y., Li Z., Wasik M., Klein-Szanto A. J., Rustgi A. K., and Diehl J. A.
Cancer Discov 5 (3): 288-303 (2015).