Dr. Man-Sun Sy received his B.A. from the University of Colorado in 1973, continuing on to earn an M.A. and a Ph.D. in 1979. From 1979 until 1992, he was on the faculty at Harvard Medical School, in the Department of Pathology, as an Instructor, Assistant Professor, and Associate Professor. Presently, Dr. Sy is a Professor of Pathology and of Medical and Neurosciences at Case's School of Medicine.
Research Information
Research Projects
The laboratory focuses on:
- Basic prion biology
- Pathogenesis of prion disease
- The role prions plays in human cancer
Publications
Prion in human cancers
Li, C.Y., Yu, S., Nakamura, F., Yin, S., Xu, J., Patrolla, A.A., Singh, N., Tartakoff, T., Abbott, D. W., X, Wei., and Sy, M.S. (2009). J. Clin. Invest. 119:2725-2736.
Sy M.S., C. Li and Wei X., 2010. . Biomark Med. 2010 Jun. 4(3): 453-64.
Li, C.Y., Yu, S., Nakamura, F., Pentikainen, O.T., Singh, N., Yin, S., X, Wei., and Sy, M.S. 2010. . J. Biol. Chem. (Epubl July 21, ahead of print).
Li, C., Wei, X and Sy, M.S., 2010. . Oncogene (Epubl. Aug. 9, 2010).
Biology of normal cellular prion and pathogenesis of prion diseases
Yin, S., Yu, S., Li, C.Y., Wong, P., Chang, B., Xiao, F., Kang, S.C., Yan, H., Xiao, G., Grassi, J., Tien, P., and Sy, M.S. (2006). . J. Biol. Chem. 281:10698-10705.
Yu, S., Yin, S., Li, C., Wong, P., Chang, B., Xiao, F., Kang, S.C., Yan, H., Xia, G., Tein, P., and Sy, M.S. (2007). . Biochemical J. 403:343-351.
Yin S., Pham, N., Yu, S., Li, C.Y., Wong, P., Chang, B.G., Kang, S.C., Biasini, E., Harris, D. A., and Sy, M. S. (2007). . Proc. Nat. Acad. Sci. (USA) 104:7546-7551.
Yin, S.M., Fan, X.G., Yu. S.L., Li., C.Y., and Sy, M.S. (2008). . J. Biol. Chem. 283: 25446-25454.
Yu, S., Yin, S., Pham, N., Wong, P., Kang, S.C., Petersen, R. B., Li, C., and Sy, M. S. (2008). . The FEBS, J. 275:5564-5575.
Sy M.S. (2009). . Cell Res. 2009 Sep;19(9):1039-40. doi: 10.1038/cr.2009.102. Epub 2009 Sep 3.