In person in Sears 439
Neural Engineering Center Seminar, BME, ÐÇ¿Õ´«Ã½
Speaker: Francine Graham
Advisors: Jeffrey Capadona and Efstathios Karathanasis
Title: Attenuating the inflammatory response to intracortical microelectrodes (IMEs) via lipid nanoparticle (LNP)-mediated siRNA delivery
Abstract: Intracortical microelectrodes (IMEs) allow for single-neuron recording, enabling neural recording for use in prosthetics and rehabilitation for patients with spinal cord injury. IMEs fail over time, in large part due to inflammation around the implant. A major contributor to the inflammatory response around the implant is the broaching of the blood brain barrier, a biological barrier that typically restricts bodily immune cells from reaching the brain. As a result, circulating immune cells mount an inflammatory immune response to damaged brain cells. This becomes a self-perpetuating process, as inflammatory signaling encourages further circulatory immune infiltration. Ultimately, this inflammation leads to electrode failure due to increased impedance and neuronal death.
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