Neural Engineering Center PhD defense
Nabeel H. Chowdhury
Ph.D. Candidate
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Department of Biomedical Engineering
Cleveland, OH
Thesis Advisor: Dr. Dustin J. Tyler, Ph. D.
9:00 AM, Monday, October 28, 2024
3rd Floor Bioenterprise Building (11000 Cedar Ave)
Academy Hub (Rm. 348)
ABSTRACT
This dissertation focuses on non-perceptual effects of artificial sensation measured by effects in the motor system. Tactile feedback is used throughout the brain, from the “highest” cortical level to the “lower” spinal or brain stem level. Touch is first used before perception, or pre-perceptually, by the brain stem in simple, automatic modulation of the motor system. For example, carrying an object from place to place or even shifting it in one’s hand involves many changing tactile signals. Even a single ridge of a fingertip supplies a unique signal for use in object manipulation. If one had to actively perceive and act upon all this information, merely picking up an object would become overwhelming. Fortunately, the lower levels of our brain automatically make minor adjustments to grip based on tactile information. What is not known is how relevant perceptual qualities are to these automatic corrections to grip. The cortex, not the brainstem, is the location of tactile perception, so it stands to reason that the brainstem does not require “natural” qualities of tactile feedback. Our lab has a group of participants with peripheral nerve cuff electrodes we can stimulation through. We tested how well artificial tactile feedback would integrate with the sensorimotor system in tasks of increasing complexity. We found that peripheral nerve stimulation is processed similarly to naturally generated touch with and without perception and may engage with the motor system as seen by the intent to modulate grip force.