I study RNA systems biology in precision medicine.
Research Information
Research Interests
Human diseases are caused by the interplay between gene and environment. Deep sequencing reveals millions of mutations between the genomes of unrelated individuals; however, the consequences of these mutations remain mostly unclear. Besides genetic impact, the actual development of individuals' disease phenotypes is largely subjected to their lifestyle, behavior, and environmental exposures. Characterizing these highly diverse and dynamic factors goes beyond what can be achieved with regular medical records.
To enable precision medicine and health, my lab seeks to address these gaps by investigating the areas which have not been extensively studied before. On the genetic side, we will focus on investigating the impact of genetic variation on post-transcriptional regulation to study the mechanistic role of RNA binding proteins in human diseases. On the non-genetic side, we will exploit the emerging wearable technology for deep phenotypical and environmental profiling. With the big data strategy integrating multi-omics, phenotypical, and environmental datasets, we are delineating the gene-environment interaction at a personal resolution to achieve precise understandings of human diseases.
Research Projects
Visit the Li
Publications
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Hong L, Herjan T, Chen X, Zagore LL, Bulek K, Wang H, Yang CJ, Licatalosi DD, Li X*, Li X*.
J Exp Med. 221(7). (2024) -
Beqari J, Powell J, Hurd J, Potter AL, McCarthy M, Srinivasan D, Wang D, Cranor J, Zhang L, Webster K, Kim J, Rosenstein A, Zheng Z, Lin TH, Li J, Fang Z, Zhang Y, Anderson A, Madsen J, Anderson J, Clark A, Yang ME, Nurko A, El-Jawahri AR, Sundt TM, Melnitchouk S, Jassar AS, D'Alessandro D, Panda N, Schumacher-Beal LY, Wright CD, Auchincloss HG, Sachdeva UM, Lanuti M, Colson YL, Langer N, Osho A, Yang CJ*, Li X*. Ann Surg. (2024)
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Li Y, Tan M, Akkari-Henić A, Zhang L, Kip M, Sun S, Sepers JJ, Xu N, Ariyurek Y, Kloet SL, Davis RP, Mikkers H, Gruber JJ, Snyder MP*, Li X*, Pang B*. Nat Biomed Eng. (2024)
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Li X*+, Perelman D+, Leong AK, Fragiadakis G, Gardner CD*, Snyder MP*. Cell Rep Med. 3(12):100870 (2022)
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Chen X, Zhao J, Herjan T, Hong L, Liao Y, Liu C, Vasu K, Wang H, Thompson A, Fox PL, Gastman BR, Li X*, Li X*. J Exp Med. 219(6) (2022)
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​Liu W, Zhou H, Wang H, Zhang Q, Zhang R, Willard B, Liu C, Kang Z, Li X*, Li X*. Nat Commun. 18;13(1):2748 (2022)
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Powell J, Li X. Cell Syst. 13(3):201-203 (2022)
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Bahmani A, Alavi A, Buergel T, Upadhyayula S, Wang Q, Ananthakrishnan SK, Alavi A, Celis D, Gillespie D, Young G, Xing Z, Nguyen MHH, Haque A, Mathur A, Payne J, Mazaheri G, Li JK, Kotipalli P, Liao L, Bhasin R, Cha K, Rolnik B, Celli A, Dagan-Rosenfeld O, Higgs E, Zhou W, Berry CL, Van Winkle KG, Contrepois K, Ray U, Bettinger K, Datta S, Li X*, Snyder MP*. Nat Commun. 12(1):5757 (2021)
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Zhao J, Liao Y, Miller-Little W, Xiao J, Liu C, Li X, Li X*, Kang Z*.J Neuroinflammation. 18(1):98 (2021)
- Yang Y., Li X., Ma Z., Wang C., Yang Q., Hong R., Min Q., Zhou G., Cheng Y., Qin G., Youngyunpipatkul J., Byrne-Steele M., Wing J., Sakaguchi S., Wang Y., Toonstra C., Wang L., Vilches-Moure J., Wang D., Snyder M., Han J., Herzenberg L.
Nat Commun. 12(1):525 (2021) - Mishra T., Wang M., Metwally A., Bogu G., Brooks A., Bahmani A., Alavi A., Celli A., Higgs E., Dagan-Rosenfeld O., Fay B., Kirkpatrick S., Kellogg R., Gibson M., Wang T., Hunting E., Mamic P., Ganz A., Rolnik B., Li X*., Snyder MP*.
Nat Biomed Eng 4, 1208–1220 (2020) - Lihua J., Wang M., Lin S., Jian R., Li X., Chan J., Fang H., Dong G., GTEx Consortium, Snyder MP.
Cell 183 (1), 269– 283e19 (2020) - Kobayashi Y., Tremblay-Gravel M., Boralkar K.A., Li X., Nishi T., Amsallem M., Moneghetti K.J., Bouajila S., Selej M., Ozen M.O., Demirci U., Ashley E., Wheeler M., Knowlton K.U., Kouznetsova T., Haddad F.
Sci Rep. 9(1):10431 (2019) - Li J., Li X., Zhang S., Snyder M.
Cell 177(1):38-44 (2019) - Zhou H.*, Bulek K.*, Li X.*, Herjan T.*, Yu M., Qian W., Wang H., Zhou G., Chen X., Yang H., Hong L., Zhao J., Qin L., Fukuda K., Flotho A., Gao J., Dongre A., Carman J.A., Kang Z., Su B., Kern T.S., Smith J.D., Hamilton T.A., Melchior F., Fox P.L., Li X.
eLife 6: e29630 (2017) - Li X.*, Dunn J.*, Salins D.*, Zhou G., Zhou W., Rose M.S., Perelman D., Colbert E., Runge R., Rego S., Sonecha R., Datta S., McLaughlin T., Snyder M.P.
PLOS Biol. 15(1): e2001402 (2017) - Li X.*, Kazan H.*, Lipshitz H.D., Morris Q.D.
Wiley Interdiscip Rev RNA 5:111-130 (2014) - Laver J.D.*, Li X.*, Ancevicius K.*, Westwood J.T., Smibert C.A., Morris Q.D., Lipshitz H.D.
Nucleic Acids Res. 41:9438-9460. (2013) - Li X., Quon G., Lipshitz H.D., Morris Q.
RNA 16:1096-1107 (2010)