Research Information
Research Interests
Our laboratory seeks to understand mechanisms of neural circuit dysfunction in autism spectrum disorders (ASDs) and to develop new therapeutic approaches. We use behavioral, electrophysiological, biochemical, imaging and morphometric techniques in genetic mouse models of ASDs to define how perturbations in synaptic signaling alter normal behavior. A portion of our research program is dedicated to preclinical evaluation of novel therapeutics for Rett syndrome and other ASDs, with a particular focus on molecules that target TrkB and NMDA receptors. Under the auspices of the Autism Spectrum Research Consortium, directed by Dr. Katz, we also collaborate with clinical faculty here at ÐÇ¿Õ´«Ã½ and elsewhere to foster human trials of potential new pharmacotherapies for ASDs.
Publications
Selected Publications
Katz, D.M., Bird, A., Coenraads, M., Gray, S., Menon, D., Philpot, B.D., Tarquinio, D. (2016)
. Trends Neurosci. 2016 Feb;39(2):100-113. doi: 10.1016/j.tins.2015.12.008.
Sceniak, M.P., Lang, M., Enomoto, A.C., Howell, C., Hermes, D.J., Katz, D.M. (2015)
. Cereb Cortex. 2016 May;26(5):1938-1956. doi: 10.1093/cercor/bhv002. Epub 2015 Feb 7.
Kron, M., Adams, I., Lang, M., Longo, F. and D.M. Katz (2014)
. Disease Models & Mechanisms. 7(9):1047-55.
Katz, D.M. (2014)
"Brain derived neurotrophic factor and Rett syndrome in Neurotrophic Factors." Handbook of Experimental Pharmacology. G.R. Lewin and B.D. Carter, Eds.; 220:481-495 Springer-Verlag, Berlin.
Buchovecky, C.M., Brown, H.M., Huang, W., Coenraads, M., Crowe, J.K., Schrock, M.V., Probst, F.J., Katz, D.M., Shendure, J. and M.J. Justice (2013)
. Nature Genetics. 45:1013-20.
Ogier, M., Kron, M. and Katz, D.M. (2013)
. Compr. Physiol. 3:1125-34.
Katz DM, Berger-Sweeney JE, Eubanks JH, Justice MJ, Neul JL, Pozzo-Miller L, Blue ME, Christian D, Crawley JN, Giustetto M, Guy J, Howell CJ, Kron M, Nelson SB, Samaco RC, Schaevitz LR, (2012)
. Disease Models and Mechanisms. 5:733-45.
Kron, M., Howell, C. J., Adams, I.T., Ransbottom, M., Christian, D., Ogier, M. and D. M. Katz (2012)
J. Neurosci. 32(40):13860-72.
Schmid, D., Yang, T., Ogier, M., Adams, I., Mirakhur, Y., Wang, Q., Massa, S., Longo, F. and D.M. Katz (2012)
.J. Neurosci. 32:1803-10.
Shepherd, G. and D.M. Katz (2011)
Current Opinion in Neurobiology. 21:827-33.
Clark, C.G., Hasser, E.M., Kunze, D.L., Katz, D.M. and D.D.Kline (2011)
.J. Neurosci. 31:12318-29.
Kline, D., Ogier, M., Kunze, D. and D.M. Katz (2010)
J. Neurosci. 30:5303-10.
Taneja, P., Ogier, M., Brooks-Harris, G., Katz, D.M. and S. B. Nelson (2009)
J. Neurosci. 29:12187-12195.
Katz, D.M., Dutschmann, M., Ramirez, N. and G. Hilaire (2009)
Resp. Physiol. and Neurobiol. 168:101-8.
Bouvier, J., Autran, S., Dehorter, N., Katz, D.M., Champagnat, J., Fortin, G. and Thoby-Brisson, M. (2008)
. Eur J Neurosci. 2008 Aug;28(3):510-20. doi: 10.1111/j.1460-9568.2008.06345.x.
Ogier, M., Wang H., Hong, E., Wang, Q., Greenberg, M.E. and D. M. Katz. (2007)
. J Neurosci. 27:10912-7.
Wang, H., Chan, S., Ogier, M., Hellard, D., Wang, Q., Smith, C. and D.M. Katz. (2006)
. J Neurosci. 26:10911-10915.
Wang, H., Yuan, G., Ward, N., Boswell, M. and D.M. Katz. (2006)
. Eur J Neurosci. 2006 Mar;23(6):1665-70.
Guo H, Hellard DT, Huang L, Katz DM. (2005)
. Eur J Neurosci. 2005 Apr; 21(7):2019-2023.
Hellard D, Brosenitsch T, Fritzsch B, Katz DM. (2004)
. Dev Biol. 2004 Nov 1; 275(1):34-43.
Thoby-Brisson M, Cauli B, Champagnat J, Fortin G, Katz DM. (2003)
. J Neurosci. 2003 Aug 20; 23(20):7685-7689.
Balkowiec A, Katz DM. (2002)
J Neurosci. 2002 Dec 1; 22(23):10399-10407.
Brosenitsch TA, Katz DM. (2002)
. Mol Cell Neurosci. 2002 Jul; 20(3):447-457.
Brosenitsch TA, Katz DM. (2001)
. J Neurosci. 2001 Apr 15; 21(8):2571-2579.
Erickson JT, Brosenitsch TA, Katz DM. (2001)
J Neurosci. 2001 Jan 15; 21(2):581-589.
Balkowiec A, Katz DM. (2000)
. J Neurosci. 2000 Oct 1; 20(19):7417-7423.
Balkowiec A, Kunze DL, Katz DM. (2000)
. J Neurosci. 2000 Mar 1; 20(5):1904-1911.
Balkowiec A, Katz DM. (1998)
. J Physiol. 1998 Jul 15; 510 ( Pt 2):527-533.
Katz DM, Balkowiec A. (1997)
. Curr Opin Pulm Med. 1997 Nov; 3(6):433-439.
Erickson JT, Conover JC, Borday V, Champagnat J, Barbacid M, Yancopoulos G, Katz DM. (1996)
. J Neurosci. 1996 Sep 1; 16(17):5361-5371.
Conover JC, Erickson JT, Katz DM, Bianchi LM, Poueymirou WT, McClain J, Pan L, Helgren M, Ip NY, Boland P, et al.. (1995)
. Nature. 1995 May 18; 375(6528):235-238.