NPDPSC Newsfeed

 

Aside from testing and surveilling prion disease, an additional aim is to provide accurate information regarding this disease through various outreach efforts. To convey information about prion disease in general and how our center operates, our faculty and staff continuously engage with the public through podcasts, virtual talks and seminars, published articles, and research papers.

Below are some publications and talks, grouped by category.

 

Please from Mark Cohen, M.D. for the 2020 American Association of Neuropathologists meeting regarding what every neuropathologist should know about prion diseases. In this talk, Dr. Cohen discusses different types of prion testing performed at the National Prion Disease Pathology Surveillance Center (NPDPSC), prion disease in general, and some information regarding our center. 

For more information on:


Take a  where our Center's director, Brian Appleby M.D., gives an update on the work of the National Prion Disease Pathology Surveillance Center (NPDPSC). In this update, Dr. Appleby briefly talks about research studies at the center; our testing procedures and Autopsy program; a brief introduction to our Center's staff; and the NPDPSC center in the environment of COVID-19.
 
  1.  - the most recent podcast interview about prion diseases, where Staff Writer from talks with host Sarah Crespi about new potential treatments for these fatal neurodegenerative diseases.
    The complete transcript of the conversation can be found 
     
  2.  - a podcast interview of Dr. Appleby with the American Chemical Society's award-winning science podcast Tiny Matters. In this episode, they discuss what are prion diseases, their various causes, and some of the work being done currently to detect them. 
     
  3. Please  to the ±·±ð³Ü°ù´Ç±ô´Ç²µ²â®&²Ô²ú²õ±è;podcast interview with Brian Appleby, M.D., in which the Center's published research on the Neurology Journal website, titled "Diagnosis of prion diseases by RT-QuIC results in improved surveillance" is discussed.

    If you want to learn more about CSF and RT-QuIC testing, you can visit and read the Cerebrospinal Fluid Diagnostic Tests page on our website. 
 

, a Staff Writer from Science, published an article titled . The article gives an overview of prion disease, with a focus on genetic CJD and the new Ionis clinical trial.

is a premier global institution dedicated to the advancement and dissemination of scientific knowledge.

Related to this article, Meredith also participated in a podcast episode called . The complete transcript of the conversation can be found 


Our Autopsy Coordination team published this informative article in The Director regarding the stigma of prion disease faces with regard to autopsies and/or burial services. The article gives an overview of prion disease, some of its characteristics, and more importantly - provides important information about the requirements of burial and/or cremation services for patients with prion disease. 

If you want to learn more about our Autopsy Program, please visit our Autopsy Coordination Program page, where you can read some of the Frequently Asked Questions, and also contact information, should you have any other questions.

For some more in depth information about recent findings in the world of prion disease, please take a look at the listed publications.

  1. Bayazid, R., Orru’, C., Aslam, R. et al. A novel subtype of sporadic Creutzfeldt–Jakob disease with PRNP codon 129MM genotype and PrP plaquesActa Neuropathol (2023).
  2. Venkatraghavan, V, Pascuzzo, R, Bron, EE, et al. A discriminative event-based model for subtype diagnosis of sporadic Creutzfeldt-Jakob disease using brain MRIAlzheimer's Dement. 2023; 1- 11. 
  3. Appleby BS, Shetty S, Elkasaby M.  Genetic aspects of human prion diseases.  Front Neurol 2022;13:1003056 
  4. Figgie MP Jr, Appleby BS. Clinical Use of Improved Diagnostic Testing for Detection of Prion Disease. Viruses. 2021 Apr 28;13(5):789 
  5. Hermann P, Appleby B, Brandel JP, Caughey B, Collins S, Geschwind MD, Green A, Haïk S, Kovacs GG, Ladogana A, Llorens F, Mead S, Nishida N, Pal S, Parchi P, Pocchiari M, Satoh K, Zanusso G, Zerr I. Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease. Lancet Neurol. 2021 Mar;20(3):235-246 
  6. Brennecke N, Cali I, Mok TH, Speedy H, Genomics England Research Consortium, Hosszu LLP, Stehmann C, Cracco L, Puoti G, Prior TW, Cohen ML, Collins SJ, Mead S, Appleby BS. Characterization of Prion Disease Associated with a Two-Octapeptide Repeat Insertion. Viruses. 2021 Sep 8;13(9):1794 /