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Janna Kiselar, PhD is an Assistant Professor of the Department of Nutrition and Associate Director of the CCC Case Proteomics SR at ÐÇ¿Õ´«Ã½. Dr. Kiselar has a national reputation in the field of covalent labeling/MS research and structural biology with over 40 publications. She has over twenty years of experience in the field of mass spectrometry, proteomics and structural biology. Dr. Kiselar’s contributions to science highlight her long-standing track record of developing innovative methodology in immunology for studding antigen-antibody interactions, mass spectrometry-based protein footprinting a well-known and popular MS-based technology for examining protein structure and dynamics, and qualitative and quantitative mass spectrometry and proteomics. Recently, she pioneered major technical advances in mass spectrometry-based protein footprinting that revolutionized impact of protein footprinting on biology and biophysics. This includes introducing single residue-based hydroxyl radical footprinting (HRF) methods which have allowed us to study historically-challenging problems in structural biology such as the interactions of amyloidogeneic proteins and intrinsically disordered proteins, and identification of drug target binding sites for both small molecules and biologics that often cannot be addressed by other structural techniques.

As the Associate Director of the Proteomics SR for Case Comprehensive Cancer Center and P30 grant Co-director, Dr. Kiselar facilitated successful collaboration with many PIs from ÐÇ¿Õ´«Ã½ and nationwide to drive the development of new biomarkers and therapeutics in cancer that resulted in high impact publications in Cell, JCI, Nature Com., Science Advances and PNAS.