Research Information
Research Interests
The Hoffer laboratory focuses on studies of Parkinson’s Disease (PD) and Traumatic Brain Injury (TBI). Our work involves both rats and mice, with an emphasis on repositioning drugs that are currently in use for other diseases such as Type 2 diabetes mellitus. Techniques that are used for our PD studies include lesion models such as MPTP and 6OHDA, as well as transgenic mice. Techniques that are used for TBI include weight drop, controlled cortical impact, and fluid percussion injury. We measure behavior, as well as immunocytochemistry and biochemical correlates of behavior changes. We collaborate with a number of laboratories both domestic and foreign. Our foreign collaborations have major research programs in Sweden, Finland, and Taiwan. A number of our projects have strong translational aspects with our “proof of principal” data supporting current and future clinical trials both in PD and TBI.
Publications
Selected Publications
Tweedie D, Rachmany L, Rubovich V, Li Y, Holloway HW, Lehrmann E, Zhang Y, Becker KG, Perez E, Hoffer BJ, Pick CG, Greig NH. . Alzheimers Dement. 2016 Jan;12(1):34-48. doi: 10.1016/j.jalz.2015.07.489. Epub 2015 Aug 29.
Ross JM, Stewart JB, Hagström E, Brene S, Brene S, Mourier A, Coppotelli G, Freyer C, Lagouge M, Hoffer BJ, Olson L, Larsson N-G. . Nature (2013). 2013 Sep 19:501(7467): 412-5. PMID:23965628.
Sterky FH , Pernold K, Harvey BK, Lindqvist E, Hoffer BJ, Olson L. . Cell Transplantation (2013) 22(9):1529-1539. Epub ahead of print (10/8/2012).
Baratz R, Tweedie D, Rubovitch V, Luo W, Seon J, Hoffter BJ, Greig NH, Pick CG. . Journal of Neurochemistry (2011) Sept;118(6):1032-42.
Rubovitch V, Ten-Bosch M, Zohar O, Harrison CR, Tempel-Brami C, Stein E, Hoffer B, Balaban C, Schreiber S, Chiu W-T, Pick CG. . Experimental Neurology. (2011) Dec;232(2): 280-9.
Good, Cameron H., Hoffman, Alexander F., Hoffer, Barry J., Chefer, Vladimir I., Shippenberg, Toni S., Bäckman, Cristina M., Larsson, Nils-Göran , Olson, Lars, Gellhaar, Sandra, Galter, Dagmar, Lupica, Carl R. . FASEB Journal. (2011) 25(4):1333-1344.
Ross JM, Oberg J, Brene S, Coppotelli G, Terzioglu M, Pernold K, Goiny M, Sitnikov R, Kehr J, Trifunovic A, Larsson NG, Hoffer BJ, Olson L. . PNAS. (2010) Nov 16; 107(46):20087-20092.
Galter D, Pernold K, Yoshitake T, Lindquist E, Hoffer B, Kehr J, Larsson N.-G, Olson L. . Genes, Brain and Behavior. (2010) Mar 1; 9(2):173-181.
Karlén A, Karlsson TE, Mattsson A, Lundströmer K, Codeluppi S, Pham TM, Bäckman CM, Ogren SO, Aberg E, Hoffman AF, Sherling MA, Lupica CR, Hoffer BJ, Spenger C, Josephson A, Brené S, Olson L. . Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20476-81.
Li Y, Perry T, Kindy MS, Harvey BK, Tweedie D, Holloway HW, Powers K, Shen H, Egan JM, Sambamurti K, Brossi A, Lahiri DK, Mattson MP, Hoffer BJ, Wang Y, Greig NH. . Proc Natl Acad Sci U S A. (2009) Jan 27;106(4):1285-90
Ekstrand, M.I., Terzioglu, M., Galter, G.A., Zhu, S., Hofstetter, C., Lindqvist, E., Thams, S., Bergstrand, A., Hansson, F.S., Trifunovic, A., Hoffer, B., Mohammed, A.H., Olson, L., and Larsson, N.-G. . PNAS 104(4): 1325-1330, 2007.
Tweedie, D., Milman, A., Holloway, H.W., Li, Y., Harvey, B.K., Shen, H., Pistell, P.J., Lahiri, D.K., Hoffer, B.J., Wang, Y., Pick, CG, and Greig, N.H. . J. Neurosci. Res. 85(4): 805-15, 2007.