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Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ \(1998\) Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different per:13) /S /GoTo >> endobj 33 0 obj << /Rect [ 83.826599 448.98999 93.5466 438.98999 ] /Subtype /Link /A 34 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 34 0 obj << /D (0002000676.INDD: 11. Liu H, Radisky DC, Wang F, Bissell MJ \(2004\) Polarity and proliferation are controlled by distinct signaling pathways downstream of pi3-kinase in breast epithelial tumor cells. J Cell Biol 164\(4\):603 612:14) /S /GoTo >> endobj 35 0 obj << /Rect [ 296.942993 412.98999 306.662994 402.98999 ] /Subtype /Link /A 36 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 36 0 obj << /D (0002000676.INDD: 12. 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Durand RE, Olive PL \(2001\) Resistance of tumor cells to chemo-and radiotherapy modulated by the three-dimensional architecture of solid tumors and spheroids. Methods Cell Biol 64:211 233:17) /S /GoTo >> endobj 41 0 obj << /Rect [ 347.109009 388.98999 356.82901 378.98999 ] /Subtype /Link /A 42 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 42 0 obj << /D (0002000676.INDD: 15. Hauptmann S, Denkert C, Lohrke H, Tietze L, Ott S, Klosterhalfen B, Mittermayer C \(1995\) Integrin expression on colorectal tumor cells growing as monolayers, as multicellular tumor spheroids, or in nude mice. Int J Cancer 61\(6\):819 825:18) /S /GoTo >> endobj 43 0 obj << /Rect [ 162.507004 268.98999 172.507004 258.98999 ] /Subtype /Link /A 44 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 44 0 obj << /D (0002000676.INDD: 16. 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Cai W, Chen X \(2008\) Multimodality molecular imaging of tumor angiogenesis. J Nucl Med 49\(Suppl 2\):113S 128S:24) /S /GoTo >> endobj 55 0 obj << /Rect [ 268.300995 148.990005 278.300995 138.990005 ] /Subtype /Link /A 56 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 56 0 obj << /D (0002000676.INDD: 25. Boehm T, Folkman J, Browder T, O Reilly MS \(1997\) Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 390\(6658\):404 407:25) /S /GoTo >> endobj 57 0 obj << /Rect [ 283.045013 148.990005 293.045013 138.990005 ] /Subtype /Link /A 58 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 58 0 obj << /D (0002000676.INDD: 26. Browder T, Butterfield CE, Kraling BM, Shi B, Marshall B, O Reilly MS, Folkman J \(2000\) Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. 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Breslin S, O Driscoll L \(2013\) Three-dimensional cell culture: the missing link in drug discovery. Drug Discov Today 18\(5 6\):240 249:28) /S /GoTo >> endobj 67 0 obj << /Rect [ 129.710007 328.98999 139.710007 318.98999 ] /Subtype /Link /A 68 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 68 0 obj << /D (0002000676.INDD: 29. Soares CP, Midlej V, Oliveira M, Benchimol M, Costa ML, Mermelstein C \(2012\) 2d and 3d-organized cardiac cells shows differences in cellular morphology, adhesion junctions, presence of myofibrils and protein expression. 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Lin R-Z, Chu W-C, Chiang C-C, Lai C-H, Chang H-Y \(2008\) Magnetic reconstruction of three-dimensional tissues from multicellular spheroids. Tissue Eng Part C Methods 14\(3\):197 205:42) /S /GoTo >> endobj 153 0 obj << /Rect [ 98.557503 508.98999 108.557999 498.98999 ] /Subtype /Link /A 154 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 154 0 obj << /D (0002000676.INDD: 39. Lin R-Z, Chu W-C, Chiang C-C, Lai C-H, Chang H-Y \(2008\) Magnetic reconstruction of three-dimensional tissues from multicellular spheroids. Tissue Eng Part C Methods 14\(3\):197 205:43) /S /GoTo >> endobj 155 0 obj << /Rect [ 293.407013 484.98999 303.407013 474.98999 ] /Subtype /Link /A 156 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 156 0 obj << /D (0002000676.INDD: 40. Tasoglu S, Kavaz D, Gurkan UA, Guven S, Chen P, Zheng R, Demirci U \(2013\) Paramagnetic levitational assembly of hydrogels. Adv Mater 25\(8\):1137 1143:44) /S /GoTo >> endobj 157 0 obj << /Rect [ 308.407013 484.98999 318.407013 474.98999 ] /Subtype /Link /A 158 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 158 0 obj << /D (0002000676.INDD: 42. Xu F, Wu CAM, Rengarajan V, Finley TD, Keles HO, Sung YR, Li BQ, Gurkan UA, Demirci U \(2011\) Three-dimensional magnetic assembly of microscale hydrogels. Adv Mater 23\(37\):4254 4260:45) /S /GoTo >> endobj 159 0 obj << /Rect [ 137.945999 316.98999 147.945999 306.98999 ] /Subtype /Link /A 160 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 160 0 obj << /D (0002000676.INDD: 43. Barzegari A, Saei AA \(2012\) An update to space biomedical research: tissue engineering in microgravity bioreactors. 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Becker JL \(2013\) Cellular biotechnology operations support systems: evaluation of ovarian tumor cell growth and gene expression \(cboss-01-ovarian\). http://www.nasa.gov/mission_pages/station/research/experiments/248.html:48) /S /GoTo >> endobj 170 0 obj << /Rect [ 256.289001 328.959991 266.289001 318.959991 ] /Subtype /Link /A 171 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 171 0 obj << /D (0002000676.INDD: 48. Jessup JM \(2013\) Cellular biotechnology operations support systems: use of NASA bioreactor to study cell cycle regulation: mechanisms of colon carcinoma metastasis in microgravity. http://www.nasa.gov/mission_pages/station/research/experiments/C:49) /S /GoTo >> endobj 172 0 obj << /Rect [ 307.27301 160.960007 317.27301 150.960007 ] /Subtype /Link /A 173 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 173 0 obj << /D (0002000676.INDD: 49. Navran S \(2008\) The application of low shear modeled microgravity to 3-d cell biology and tissue engineering. In: El-Gewely MR \(ed\) Biotechnology annual review, vol 14. Elsevier, Amsterdam, pp 275 296:50) /S /GoTo >> endobj 174 0 obj << /Rect [ 329.165009 148.960007 361.368988 138.960007 ] /Subtype /Link /A 175 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 175 0 obj << /D (0002000676.INDD:Fig00244 0:251) /S /GoTo >> endobj 176 0 obj << /Rect [ 57.0882 76.959503 66.888199 66.959503 ] /Subtype /Link /A 177 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 177 0 obj << /D (0002000676.INDD: 50. Begley CM, Kleis SJ \(2002\) Rwpv bioreactor mass transport: earth-based and in microgravity. Biotechnol Bioeng 80\(4\):465 476:51) /S /GoTo >> endobj 178 0 obj << /Rect [ 72.2733 76.959503 82.073303 66.959503 ] /Subtype /Link /A 179 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 179 0 obj << /D (0002000676.INDD: 51. Barrila J, Radtke AL, Crabb A, Sarker SF, Herbst-Kralovetz MM, Ott CM, Nickerson CA \(2010\) Organotypic 3d cell culture models: Using the rotating wall vessel to study host pathogen interactions. 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Chen HC, Hu YC \(2006\) Bioreactors for tissue engineering. Biotechnol Lett 28\(18\): 1415 1423:53) /S /GoTo >> endobj 188 0 obj << /Rect [ 315.263 580.98999 325.263 570.98999 ] /Subtype /Link /A 189 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 189 0 obj << /D (0002000676.INDD: 52. Freed LE, Langer R, Martin I, Pellis NR, Vunjak-Novakovic G \(1997\) Tissue engineering of cartilage in space. Proc Natl Acad Sci 94\(25\):13885 13890:54) /S /GoTo >> endobj 190 0 obj << /Rect [ 256.531006 460.98999 266.531006 450.98999 ] /Subtype /Link /A 191 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 191 0 obj << /D (0002000676.INDD: 53. Grun B, Benjamin E, Sinclair J, Timms JF, Jacobs IJ, Gayther SA, Dafou D \(2009\) Three-dimensional in vitro cell biology models of ovarian and endometrial cancer. Cell Prolif 42\(2\):219 228:55) /S /GoTo >> endobj 192 0 obj << /Rect [ 234.005005 388.98999 244.005005 378.98999 ] /Subtype /Link /A 193 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 193 0 obj << /D (0002000676.INDD: 49. Navran S \(2008\) The application of low shear modeled microgravity to 3-d cell biology and tissue engineering. In: El-Gewely MR \(ed\) Biotechnology annual review, vol 14. Elsevier, Amsterdam, pp 275 296:56) /S /GoTo >> endobj 194 0 obj << /Rect [ 248.623993 388.98999 258.623993 378.98999 ] /Subtype /Link /A 195 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 195 0 obj << /D (0002000676.INDD: 54. Takeda M, Magaki T, Okazaki T, Kawahara Y, Manabe T, Yuge L, Kurisu K \(2009\) Effects of simulated microgravity on proliferation and chemosensitivity in malignant glioma cells. 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Cell Transplant 14\(10\):829 835:58) /S /GoTo >> endobj 198 0 obj << /Rect [ 78.034401 328.98999 95.534401 318.98999 ] /Subtype /Link /A 199 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 199 0 obj << /D (0002000676.INDD:Table 24.2 microgravity bioreactor technologies for cancer cells:257) /S /GoTo >> endobj 200 0 obj << /Rect [ 365.511993 328.98999 383.011993 318.98999 ] /Subtype /Link /A 201 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 201 0 obj << /D (0002000676.INDD:Table 24.3 Comparison of 3D cancer cell culture technologies:258) /S /GoTo >> endobj 202 0 obj << /Rect [ 206.320999 160.990005 216.281006 150.990005 ] /Subtype /Link /A 203 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 203 0 obj << /D (0002000676.INDD: 59. Xu F, Celli J, Rizvi I, Moon S, Hasan T, Demirci U \(2011\) A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform. 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Marrero B, Messina J, Heller R \(2009\) Generation of a tumor spheroid in a microgravity environment as a 3d model of melanoma. In Vitro Cell Dev Biol Anim 45\(9\):523 534:59) /S /GoTo >> endobj 212 0 obj << /Rect [ 133.757004 594.68103 142.257004 581.93103 ] /Subtype /Link /A 213 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 213 0 obj << /D (0002000676.INDD: 173. Smith SJ, Wilson M, Ward JH, Rahman CV, Peet AC, Macarthur DC, Rose F, Grundy RG, Rahman R \(2012\) Recapitulation of tumor heterogeneity and molecular signatures in a 3d brain cancer model with decreased sensitivity to histone deacetylase inhibiti:60) /S /GoTo >> endobj 214 0 obj << /Rect [ 154.757004 591.153015 163.257004 578.403015 ] /Subtype /Link /A 215 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 215 0 obj << /D (0002000676.INDD: 174. Tang J, Cui J, Chen R, Guo K, Kang X, Li Y, Gao D, Sun L, Xu C, Chen J, Tang Z, Liu Y \(2011\) A three-dimensional cell biology model of human hepatocellular carcinoma in vitro. Tumor Biol 32\(3\):469 479:61) /S /GoTo >> endobj 216 0 obj << /Rect [ 185.757004 587.583008 194.257004 579.083008 ] /Subtype /Link /A 217 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 217 0 obj << /D (0002000676.INDD: 53. Grun B, Benjamin E, Sinclair J, Timms JF, Jacobs IJ, Gayther SA, Dafou D \(2009\) Three-dimensional in vitro cell biology models of ovarian and endometrial cancer. Cell Prolif 42\(2\):219 228:62) /S /GoTo >> endobj 218 0 obj << /Rect [ 227.757004 598.35199 236.257004 585.60199 ] /Subtype /Link /A 219 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 219 0 obj << /D (0002000676.INDD: 175. Becker JL, Blanchard DK \(2007\) Characterization of primary breast carcinomas grown in three-dimensional cultures. J Surg Res 142\(2\):256 262:63) /S /GoTo >> endobj 220 0 obj << /Rect [ 238.757004 590.63501 247.257004 577.88501 ] /Subtype /Link /A 221 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 221 0 obj << /D (0002000676.INDD: 176. Taga M, Yamauchi K, Odle J, Furian L, Sundaresan A, Ramesh GT, Pellis NR, Andrassy RJ, Kulkarni AD \(2006\) Melanoma growth and tumorigenicity in models of microgravity. Aviat Space Environ Med 77\(11\):1113 1116:64) /S /GoTo >> endobj 222 0 obj << /Rect [ 259.756989 591.833008 268.256989 579.083008 ] /Subtype /Link /A 223 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 223 0 obj << /D (0002000676.INDD: 177. Rhee HW, Zhau HE, Pathak S, Multani AS, Pennanen S, Visakorpi T, Chung LWK \(2001\) Permanent phenotypic and genotypic changes of prostate cancer cells cultured in a three-dimensional rotating-wall vessel. In Vitro Cell Dev Biol Anim 37\(3\):127 14:65) /S /GoTo >> endobj 224 0 obj << /Rect [ 280.756989 599.390015 289.256989 586.640015 ] /Subtype /Link /A 225 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 225 0 obj << /D (0002000676.INDD: 178. Chopra V, Dinh TV, Hannigan EV \(1997\) Three-dimensional endothelial-tumor epithelial cell interactions in human cervical cancers. Vitro Cellular & Developmental Biology-Animal 33\(6\):432 442:66) /S /GoTo >> endobj 226 0 obj << /Rect [ 291.756989 594.366028 300.256989 585.866028 ] /Subtype /Link /A 227 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 227 0 obj << /D (0002000676.INDD: 54. Takeda M, Magaki T, Okazaki T, Kawahara Y, Manabe T, Yuge L, Kurisu K \(2009\) Effects of simulated microgravity on proliferation and chemosensitivity in malignant glioma cells. 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Navran S \(2008\) The application of low shear modeled microgravity to 3-d cell biology and tissue engineering. In: El-Gewely MR \(ed\) Biotechnology annual review, vol 14. Elsevier, Amsterdam, pp 275 296:70) /S /GoTo >> endobj 237 0 obj << /Rect [ 167.257004 585.723999 175.757004 577.223999 ] /Subtype /Link /A 238 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 238 0 obj << /D (0002000676.INDD: 51. Barrila J, Radtke AL, Crabb A, Sarker SF, Herbst-Kralovetz MM, Ott CM, Nickerson CA \(2010\) Organotypic 3d cell culture models: Using the rotating wall vessel to study host pathogen interactions. Nat Rev Microbiol 8\(11\):791 801:71) /S /GoTo >> endobj 239 0 obj << /Rect [ 208.257004 572.973999 216.757004 564.473999 ] /Subtype /Link /A 240 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 240 0 obj << /D (0002000676.INDD: 38. Souza GR, Molina JR, Raphael RM, Ozawa MG, Stark DJ, Levin CS, Bronk LF, Ananta JS, Mandelin J, Georgescu M-M, Bankson JA, Gelovani JG, Killian TC, Arap W, Pasqualini R \(2010\) Three-dimensional tissue culture based on magnetic cell levitation.:72) /S /GoTo >> endobj 241 0 obj << /Rect [ 279.256989 572.973999 287.756989 564.473999 ] /Subtype /Link /A 242 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 242 0 obj << /D (0002000676.INDD: 34. Hsiao AY, Tung Y-C, Qu X, Patel LR, Pienta KJ, Takayama S \(2012\) 384 hanging drop arrays give excellent z-factors and allow versatile formation of co-culture spheroids. Biotechnol Bioeng 109\(5\):1293 1304:73) /S /GoTo >> endobj 243 0 obj << /Rect [ 279.256989 585.723999 287.756989 577.223999 ] /Subtype /Link /A 244 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 244 0 obj << /D (0002000676.INDD: 36. Tung Y-C, Hsiao AY, Allen SG, Y-s T, Ho M, Takayama S \(2011\) High-throughput 3d spheroid culture and drug testing using a 384 hanging drop array. Analyst 136\(3\):473 478:74) /S /GoTo >> endobj 245 0 obj << /Rect [ 300.256989 572.973999 308.756989 564.473999 ] /Subtype /Link /A 246 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 246 0 obj << /D (0002000676.INDD: 59. Xu F, Celli J, Rizvi I, Moon S, Hasan T, Demirci U \(2011\) A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform. Biotechnol J 6\(2\):204 212:75) /S /GoTo >> endobj 247 0 obj << /Rect [ 300.256989 585.723999 308.756989 577.223999 ] /Subtype /Link /A 248 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 248 0 obj << /D (0002000676.INDD: 62. Tasoglu S, Demirci U \(2013\) Bioprinting for stem cell research. Trends Biotechnol 31\(1\):10 19:76) /S /GoTo >> endobj 249 0 obj << /Rect [ 300.256989 598.473999 308.756989 589.973999 ] /Subtype /Link /A 250 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 250 0 obj << /D (0002000676.INDD: 68. Tasoglu S, Kaynak G, Szeri AJ, Demirci U, Muradoglu M \(2010\) Impact of a compound droplet on a flat surface: a model for single cell epitaxy. Phys Fluids 22\(8\):77) /S /GoTo >> endobj 251 0 obj << /Rect [ 310.256989 582.143005 318.756989 573.643005 ] /Subtype /Link /A 252 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 252 0 obj << /D (0002000676.INDD: 70. Muradoglu M, Tasoglu S \(2010\) A front-tracking method for computational modeling of impact and spreading of viscous droplets on solid walls. Comput Fluids 39\(4\):615 625:78) /S /GoTo >> endobj 253 0 obj << /Rect [ 310.256989 599.143005 318.756989 586.393005 ] /Subtype /Link /A 254 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 254 0 obj << /D (0002000676.INDD: 142. Anghelina M, Krishnan P, Moldovan L, Moldovan NI \(2006\) Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair-conversion of cell columns into fibrovascular bundles. 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Moon S, Ceyhan E, Gurkan UA, Demirci U \(2011\) Statistical modeling of single target cell encapsulation. PLoS One 6\(7\):e21580:85) /S /GoTo >> endobj 261 0 obj << /Rect [ 279.35199 544.669983 289.35199 534.669983 ] /Subtype /Link /A 262 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 262 0 obj << /D (0002000676.INDD: 61. Ceyhan E, Xu F, Gurkan UA, Emre AE, Turali ES, El Assal R, Acikgenc A, Wu CM, Demirci U \(2012\) Prediction and control of number of cells in microdroplets by stochastic modeling. Lab on a Chip. doi:10.1039/C1032LC40523G:86) /S /GoTo >> endobj 263 0 obj << /Rect [ 353.084015 496.670013 363.084015 486.670013 ] /Subtype /Link /A 264 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 264 0 obj << /D (0002000676.INDD: 60. Moon S, Ceyhan E, Gurkan UA, Demirci U \(2011\) Statistical modeling of single target cell encapsulation. 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Tasoglu S, Gurkan UA, Wang A, Demirci U \(2013\) Manipulating biological agents and cells in microscale volumes for applications in medicine. Chem Soc Rev 13\(42\):5788 5808:90) /S /GoTo >> endobj 274 0 obj << /Rect [ 342.968994 364.670013 352.968994 354.670013 ] /Subtype /Link /A 275 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 275 0 obj << /D (0002000676.INDD: 65. Demirci U, Montesano G \(2007\) Cell encapsulating droplet vitrification. Lab Chip 7\(11\):1428 1433:91) /S /GoTo >> endobj 276 0 obj << /Rect [ 358.411011 364.670013 368.411011 354.670013 ] /Subtype /Link /A 277 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 277 0 obj << /D (0002000676.INDD: 66. Demirci U, Montesano G \(2007\) Single cell epitaxy by acoustic picoliter droplets. Lab Chip 7:1139 1145:92) /S /GoTo >> endobj 278 0 obj << /Rect [ 300.329987 256.670013 310.329987 246.669998 ] /Subtype /Link /A 279 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 279 0 obj << /D (0002000676.INDD: 40. Tasoglu S, Kavaz D, Gurkan UA, Guven S, Chen P, Zheng R, Demirci U \(2013\) Paramagnetic levitational assembly of hydrogels. Adv Mater 25\(8\):1137 1143:93) /S /GoTo >> endobj 280 0 obj << /Rect [ 315.329987 256.670013 325.329987 246.669998 ] /Subtype /Link /A 281 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 281 0 obj << /D (0002000676.INDD: 42. Xu F, Wu CAM, Rengarajan V, Finley TD, Keles HO, Sung YR, Li BQ, Gurkan UA, Demirci U \(2011\) Three-dimensional magnetic assembly of microscale hydrogels. Adv Mater 23\(37\):4254 4260:94) /S /GoTo >> endobj 282 0 obj << /Rect [ 331.411011 256.670013 341.411011 246.669998 ] /Subtype /Link /A 283 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 283 0 obj << /D (0002000676.INDD: 67. Gurkan UA, Tasoglu S, Kavaz D, Demirel MC, Demirci U \(2012\) Emerging technologies for assembly of microscale hydrogels. Adv Healthc Mater 1\(2\):149 158:95) /S /GoTo >> endobj 284 0 obj << /Rect [ 369.682007 232.669998 379.682007 222.669998 ] /Subtype /Link /A 285 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 285 0 obj << /D (0002000676.INDD: 68. Tasoglu S, Kaynak G, Szeri AJ, Demirci U, Muradoglu M \(2010\) Impact of a compound droplet on a flat surface: a model for single cell epitaxy. Phys Fluids 22\(8\):96) /S /GoTo >> endobj 286 0 obj << /Rect [ 249.201996 196.669998 259.201996 186.669998 ] /Subtype /Link /A 287 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 287 0 obj << /D (0002000676.INDD: 69. Kistler SF \(ed\) \(1993\) Wettability. Dekker, New York:97) /S /GoTo >> endobj 288 0 obj << /Rect [ 264.57901 196.669998 274.57901 186.669998 ] /Subtype /Link /A 289 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 289 0 obj << /D (0002000676.INDD: 70. Muradoglu M, Tasoglu S \(2010\) A front-tracking method for computational modeling of impact and spreading of viscous droplets on solid walls. Comput Fluids 39\(4\):615 625:98) /S /GoTo >> endobj 290 0 obj << /Rect [ 200.886002 172.669998 210.886002 162.669998 ] /Subtype /Link /A 291 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 291 0 obj << /D (0002000676.INDD: 68. Tasoglu S, Kaynak G, Szeri AJ, Demirci U, Muradoglu M \(2010\) Impact of a compound droplet on a flat surface: a model for single cell epitaxy. Phys Fluids 22\(8\):99) /S /GoTo >> endobj 292 0 obj << /Rect [ 228.470001 112.669998 238.470001 102.669998 ] /Subtype /Link /A 293 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 293 0 obj << /D (0002000676.INDD: 71 Tasoglu S, Rohan LC, Katz DF, Szeri AJ \(2013\) Transient swelling, spreading and drug delivery by a dissolved anti-hiv microbicide-bearing film. Phys Fluids 25\(3\):031901 031916 \(http://dx.doi.org/10.1063/1.4793598\):100) /S /GoTo >> endobj 294 0 obj << /Rect [ 301.345001 100.669998 311.345001 90.6698 ] /Subtype /Link /A 295 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 295 0 obj << /D (0002000676.INDD: 72. Szeri AJ, Park SC, Tasoglu S, Verguet S, Gorham A, Gao Y, Katz DF \(2010\) Epithelial coating mechanisms by semi-solid materials: application to microbicide gels. Biophys J 98\(3\):604:101) /S /GoTo >> endobj 296 0 obj << /Rect [ 316.345001 100.669998 326.345001 90.6698 ] /Subtype /Link /A 297 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 297 0 obj << /D (0002000676.INDD: 73. Tasoglu S, Peters JJ, Park SC, Verguet S, Katz DF, Szeri AJ \(2011\) The effects of inhomogeneous boundary dilution on the coating flow of an anti-HIV microbicide vehicle. 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Xu F, Celli J, Rizvi I, Moon S, Hasan T, Demirci U \(2011\) A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform. Biotechnol J 6\(2\):204 212:82) /S /GoTo >> endobj 307 0 obj << /Rect [ 318.220001 75.996696 326.720001 65.924202 ] /Subtype /Link /A 308 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 308 0 obj << /D (0002000676.INDD: 60. Moon S, Ceyhan E, Gurkan UA, Demirci U \(2011\) Statistical modeling of single target cell encapsulation. PLoS One 6\(7\):e21580:83) /S /GoTo >> endobj 309 0 obj << /Rect [ 113.331001 64.424202 121.831001 55.924198 ] /Subtype /Link /A 310 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 310 0 obj << /D (0002000676.INDD: 68. Tasoglu S, Kaynak G, Szeri AJ, Demirci U, Muradoglu M \(2010\) Impact of a compound droplet on a flat surface: a model for single cell epitaxy. 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Tasoglu S, Kaynak G, Szeri AJ, Demirci U, Muradoglu M \(2010\) Impact of a compound droplet on a flat surface: a model for single cell epitaxy. Phys Fluids 22\(8\):103) /S /GoTo >> endobj 317 0 obj << /Rect [ 209.070007 487.720001 219.070007 472.619995 ] /Subtype /Link /A 318 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 318 0 obj << /D (0002000676.INDD: 74. Takamatsu H, Rubinsky B \(1999\) Viability of deformed cells. Cryobiology 39\(3\):243 251:104) /S /GoTo >> endobj 319 0 obj << /Rect [ 172.106995 448.670013 182.106995 438.670013 ] /Subtype /Link /A 320 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 320 0 obj << /D (0002000676.INDD: 75. Moon S, Hasan SK, Song YS, Xu F, Keles HO, Manzur F, Mikkilineni S, Hong JW, Nagatomi J, Haeggstrom E, Khademhosseini A, Demirci U \(2010\) Layer by layer three-dimensional tissue epitaxy by cell-laden hydrogel droplets. Tissue Eng Part C Methods 1:105) /S /GoTo >> endobj 321 0 obj << /Rect [ 187.106995 448.670013 197.106995 438.670013 ] /Subtype /Link /A 322 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 322 0 obj << /D (0002000676.INDD: 78. Samot J, Moon S, Shao L, Zhang X, Xu F, Song Y, Keles HO, Matloff L, Markel J, Demirci U \(2011\) Blood banking in living droplets. PLoS One 6\(3\):e17530:106) /S /GoTo >> endobj 323 0 obj << /Rect [ 354.682007 424.670013 364.682007 414.670013 ] /Subtype /Link /A 324 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 324 0 obj << /D (0002000676.INDD: 79. Tasoglu S, Park SC, Peters JJ, Katz DF, Szeri AJ \(2011\) The consequences of yield stress on deployment of a non-newtonian anti-HIV microbicide gel. J Nonnewton Fluid Mech 166\(19 20\):1116 1122:107) /S /GoTo >> endobj 325 0 obj << /Rect [ 369.682007 424.670013 379.682007 414.670013 ] /Subtype /Link /A 326 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 326 0 obj << /D (0002000676.INDD: 81. Tasoglu S, Szeri AJ, Katz DF \(2011\) Transport processes in vaginal films that release anti-HIV microbicide molecules. Biophys J 100\(3\):489:108) /S /GoTo >> endobj 327 0 obj << /Rect [ 241.134995 292.670013 251.134995 282.670013 ] /Subtype /Link /A 328 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 328 0 obj << /D (0002000676.INDD: 82. Kleinman HK, Martin GR \(2005\) Matrigel: Basement membrane matrix with biological activity. In: Seminars in cancer biology. Elsevier, 15\(5\):378 386:109) /S /GoTo >> endobj 329 0 obj << /Rect [ 353.253998 280.670013 363.253998 270.670013 ] /Subtype /Link /A 330 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 330 0 obj << /D (0002000676.INDD: 82. 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Fridman R, Kibbey MC, Royce LS, Zain M, Sweeney TM, Jicha DL, Yannelli JR, Martin GR, Kleinman HK \(1991\) Enhanced tumor growth of both primary and established human and murine tumor cells in athymic mice after coinjection with matrigel. J Natl Ca:112) /S /GoTo >> endobj 336 0 obj << /Rect [ 109.641998 64.6698 119.741997 54.6698 ] /Subtype /Link /A 337 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 337 0 obj << /D (0002000676.INDD: 83. Fridman R, Kibbey MC, Royce LS, Zain M, Sweeney TM, Jicha DL, Yannelli JR, Martin GR, Kleinman HK \(1991\) Enhanced tumor growth of both primary and established human and murine tumor cells in athymic mice after coinjection with matrigel. 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Fridman R, Kibbey MC, Royce LS, Zain M, Sweeney TM, Jicha DL, Yannelli JR, Martin GR, Kleinman HK \(1991\) Enhanced tumor growth of both primary and established human and murine tumor cells in athymic mice after coinjection with matrigel. J Natl :114) /S /GoTo >> endobj 351 0 obj << /Rect [ 180.268005 232.990005 190.268005 222.990005 ] /Subtype /Link /A 352 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 352 0 obj << /D (0002000676.INDD: 84. Webber MM, Bello D, Kleinman HK, Hoffman MP \(1997\) Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells. Carcinogenesis 18\(6\):1225 1231:115) /S /GoTo >> endobj 353 0 obj << /Rect [ 85.827698 208.990005 95.827698 198.990005 ] /Subtype /Link /A 354 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 354 0 obj << /D (0002000676.INDD: 85. Shekhar MPV, Werdell J, Santner SJ, Pauley RJ, Tait L \(2001\) Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: Implications for tumor development and progression. Cancer Res 61\(4\):1320 1326:116) /S /GoTo >> endobj 355 0 obj << /Rect [ 369.708008 64.9897 379.708008 54.9897 ] /Subtype /Link /A 356 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 356 0 obj << /D (0002000676.INDD: 86. Adnan OA-Y, Imran R, Conor LE, Jonathan PC, Tayyaba H \(2009\) Puramatrix encapsulation of cancer cells. J Vis Exp \(34\):121) /S /GoTo >> endobj 357 0 obj << /Rect [ 209.983994 323.924988 218.483994 313.852997 ] /Subtype /Link /A 358 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 358 0 obj << /D (0002000676.INDD: 91. Gelain F, Bottai D, Vescovi A, Zhang S \(2006\) Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. 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M|!l_gf R"ٲU!E^]eđc'2FU{%wf!8BP5 V omv_"Frt5yyO,j_{RNy8^0De3ee=E%^ z#ID8ZmZvP޴rKYUA*,+T$lWg+?CE%$l@-,)莈fu=s)@L*Ҭ:a^9ͣHr~Alf0+q 4O[r\ 2m$K_"c%%gRy#|srC!ʴi&2G^MEmG}c1IHz#dAcC+4v4iʚ/f,|6W2|S)n櫥Xo|u #M<A'RV͸1@%t+Cgn<"4#T4\Cd_Uz0bĩݾS9Bʤ=zb_7844N|DN{s+J~y|~Av4}j!EKm) |@D#Xkpk8> % ;ݨ%D nȍob?0=SX`q=%ΌDQ`)y,5U= j$u&'%F5/u t7W]C4Ԁu`}*';+=N PtR'˞oeӌ9FAN?h".GHocvk:FBp1+-ؕ"I9%yPs i&XtL* 9|^;D`Ft*]{Nw y27"CAN0+r퀌.'N"PqO-|gyG@J  A+%_G=_PgIw͏Y!C1ؑECжkjP$CA&'ƥP,/ (f^+C*0Doْs,cU\kN%M#v@+|Tv!Ua@NFeyFm(6( +sX@ ܖܨəLŸ GOL@0aˈLEӣ*q0!7;+u—.wt:j/"ns *BS-B7ϝ90:}>CƱ)B~61t "~$tk]]e(31:Ri4D׌Kv:ϭZ(ҤrjNonT3u| D]80w03]FwmWLV_ j {s! ^'^M89A:|iV^hA9Z&ZեȁDs.i4w/؋rTe(/ q,O;EW})i"v~+K}fHdp,5q0{eF1 ]Uc(DmMAdzO66 [:N84i:^!qG *`ַ߼y^ީ1c5UGfIU1CGϖ O~T}cϤ^]L^UùaFÝ+o&MDr!H-|9o\,CTQR9jm% %|:/w̃UL37}!JxY}]T+|w+u!@?2a<[hNC.#F2w[ n1C3ղ)ʁ:Uᤷ9*?(ՋP=ػ崳̈́/Vc<;ΔBC"#tS0wA`NY ӽ'Jjoue؁?Z;W@Js8\Jϱ'nЍ9ԭiWх]%HqcekKa{_]aZ[-:Gqӿ-xDh%J\~mN endstream endobj 368 0 obj << /Rect [ 252.464005 580.98999 262.463989 570.98999 ] /Subtype /Link /A 369 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 369 0 obj << /D (0002000676.INDD: 87. Zhang S, Holmes T, Lockshin C, Rich A \(1993\) Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. Proc Natl Acad Sci 90\(8\):3334 3338:122) /S /GoTo >> endobj 370 0 obj << /Rect [ 269.098999 580.98999 279.098999 570.98999 ] /Subtype /Link /A 371 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 371 0 obj << /D (0002000676.INDD: 88. Zhang S, Holmes TC, DiPersio CM, Hynes RO, Su X, Rich A \(1995\) Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials 16\(18\):1385 1393:123) /S /GoTo >> endobj 372 0 obj << /Rect [ 360.911987 580.98999 383.011993 570.98999 ] /Subtype /Link /A 711 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 373 0 obj << /Rect [ 279 520.98999 289 510.98999 ] /Subtype /Link /A 374 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 374 0 obj << /D (0002000676.INDD: 32. Kleinman HK, McGarvey ML, Hassell JR, Star VL, Cannon FB, Laurie GW, Martin GR \(1986\) Basement membrane complexes with biological activity. Biochemistry 25\(2\): 312 318:124) /S /GoTo >> endobj 375 0 obj << /Rect [ 294.738007 520.98999 304.738007 510.98999 ] /Subtype /Link /A 376 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 376 0 obj << /D (0002000676.INDD: 89. Weaver VM, Howlett AR, Langton-Webster B, Petersen OW, Bissell MJ \(1995\) The development of a functionally relevant cell culture model of progressive human breast cancer. In: Seminars in cancer biology. Elsevier, 6\(3\):175 184:125) /S /GoTo >> endobj 377 0 obj << /Rect [ 309.738007 520.98999 319.738007 510.98999 ] /Subtype /Link /A 378 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 378 0 obj << /D (0002000676.INDD: 91. Gelain F, Bottai D, Vescovi A, Zhang S \(2006\) Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. 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Kim MS, Yeon JH, Park J-K \(2007\) A microfluidic platform for 3-dimensional cell culture and cell-based assays. Biomed Microdevices 9\(1\):25 34:129) /S /GoTo >> endobj 385 0 obj << /Rect [ 285.963989 412.98999 295.963989 402.98999 ] /Subtype /Link /A 386 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 386 0 obj << /D (0002000676.INDD: 93. Ranieri JP, Bellamkonda R, Bekos EJ, Vargo TG, Gardella JA, Aebischer P \(2004\) Neuronal cell attachment to fluorinated ethylene propylene films with covalently immobilized laminin oligopeptides YIGSR and IKVAV. II. J Biomed Mater Res 29\(6\):779 78:130) /S /GoTo >> endobj 387 0 obj << /Rect [ 344.641998 412.98999 354.641998 402.98999 ] /Subtype /Link /A 388 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 388 0 obj << /D (0002000676.INDD: 94. 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Caicedo-Carvajal CE, Liu Q, Remache Y, Goy A, Suh KS \(2011\) Cancer tissue engineering: a novel 3d polystyrene scaffold for in vitro isolation and amplification of lymphoma cancer cells from heterogeneous cell mixtures. J Tissue Eng 2\(1\):154) /S /GoTo >> endobj 440 0 obj << /Rect [ 293.269012 161.990005 308.269012 151.990005 ] /Subtype /Link /A 441 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 441 0 obj << /D (0002000676.INDD: 112. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM \(2005\) Tensional homeostasis and the malignant phenotype. Cancer Cell 8\(3\):241 254:155) /S /GoTo >> endobj 442 0 obj << /Rect [ 313.269012 161.990005 328.269012 151.990005 ] /Subtype /Link /A 443 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 443 0 obj << /D (0002000676.INDD: 114. Kraning-Rush CM, Reinhart-King CA \(2012\) Controlling matrix stiffness and topography for the study of tumor cell migration. Cell Adh Migr 6\(3\):274 279:156) /S /GoTo >> endobj 444 0 obj << /Rect [ 139.108994 113.989998 154.108994 103.989998 ] /Subtype /Link /A 445 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 445 0 obj << /D (0002000676.INDD: 112. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM \(2005\) Tensional homeostasis and the malignant phenotype. Cancer Cell 8\(3\):241 254:157) /S /GoTo >> endobj 446 0 obj << /Rect [ 159.597 113.989998 174.597 103.989998 ] /Subtype /Link /A 447 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 447 0 obj << /D (0002000676.INDD: 115. Chambers AF, Groom AC, MacDonald IC \(2002\) Dissemination and growth of cancer cells in metastatic sites. 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Mak M, Reinhart-King CA, Erickson D \(2011\) Microfabricated physical spatial gradients for investigating cell migration and invasion dynamics. PLoS One 6\(6\):e20825:162) /S /GoTo >> endobj 459 0 obj << /Rect [ 240.205994 484.98999 255.205994 474.98999 ] /Subtype /Link /A 460 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 460 0 obj << /D (0002000676.INDD: 116. Mak M, Reinhart-King CA, Erickson D \(2011\) Microfabricated physical spatial gradients for investigating cell migration and invasion dynamics. PLoS One 6\(6\):e20825:163) /S /GoTo >> endobj 461 0 obj << /Rect [ 343.834991 412.98999 358.834991 402.98999 ] /Subtype /Link /A 462 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 462 0 obj << /D (0002000676.INDD: 112. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM \(2005\) Tensional homeostasis and the malignant phenotype. Cancer Cell 8\(3\):241 254:164) /S /GoTo >> endobj 463 0 obj << /Rect [ 364.682007 412.98999 379.682007 402.98999 ] /Subtype /Link /A 464 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 464 0 obj << /D (0002000676.INDD: 118. Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM \(2009\) Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139\(5\):891 906:165) /S /GoTo >> endobj 465 0 obj << /Rect [ 283.175995 388.98999 298.175995 378.98999 ] /Subtype /Link /A 466 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 466 0 obj << /D (0002000676.INDD: 112. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM \(2005\) Tensional homeostasis and the malignant phenotype. 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Cell Adh Migr 6\(3\):274 279:168) /S /GoTo >> endobj 471 0 obj << /Rect [ 333.036011 364.98999 348.036011 354.98999 ] /Subtype /Link /A 472 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 472 0 obj << /D (0002000676.INDD: 119. Carey SP, Kraning-Rush CM, Williams RM, Reinhart-King CA \(2012\) Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture. Biomaterials 33\(16\):4157 4165:169) /S /GoTo >> endobj 473 0 obj << /Rect [ 317.337006 340.98999 332.337006 330.98999 ] /Subtype /Link /A 474 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 474 0 obj << /D (0002000676.INDD: 119. Carey SP, Kraning-Rush CM, Williams RM, Reinhart-King CA \(2012\) Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture. 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Cell Adh Migr 6\(3\):274 279:172) /S /GoTo >> endobj 479 0 obj << /Rect [ 170.552994 256.98999 185.552994 246.990005 ] /Subtype /Link /A 480 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 480 0 obj << /D (0002000676.INDD: 120. Provenzano PP, Inman DR, Eliceiri KW, Trier SM, Keely PJ \(2008\) Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization. Biophys J 95\(11\):5374 5384:173) /S /GoTo >> endobj 481 0 obj << /Rect [ 191.337997 256.98999 206.337997 246.990005 ] /Subtype /Link /A 482 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 482 0 obj << /D (0002000676.INDD: 121. Provenzano PP, Eliceiri KW, Campbell JM, Inman DR, White JG, Keely PJ \(2006\) Collagen reorganization at the tumor-stromal interface facilitates local invasion. BMC Med 4\(1\):38:174) /S /GoTo >> endobj 483 0 obj << /Rect [ 276.127014 256.98999 291.127014 246.990005 ] /Subtype /Link /A 484 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 484 0 obj << /D (0002000676.INDD: 122. Charest JM, Califano JP, Carey SP, Reinhart-King CA \(2012\) Fabrication of substrates with defined mechanical properties and topographical features for the study of cell migration. Macromol Biosci 12\(1\):12 20:175) /S /GoTo >> endobj 485 0 obj << /Rect [ 364.682007 184.990005 379.682007 174.990005 ] /Subtype /Link /A 486 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 486 0 obj << /D (0002000676.INDD: 123. Kraning-Rush CM, Califano JP, Reinhart-King CA \(2012\) Cellular traction stresses increase with increasing metastatic potential. PLoS One 7\(2\):e32572:176) /S /GoTo >> endobj 487 0 obj << /Rect [ 364.682007 124.989998 379.682007 114.989998 ] /Subtype /Link /A 488 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 488 0 obj << /D (0002000676.INDD: 123. Kraning-Rush CM, Califano JP, Reinhart-King CA \(2012\) Cellular traction stresses increase with increasing metastatic potential. PLoS One 7\(2\):e32572:177) /S /GoTo >> endobj 489 0 obj << /Rect [ 201.022995 88.9897 216.022995 78.9897 ] /Subtype /Link /A 490 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 490 0 obj << /D (0002000676.INDD: 123. Kraning-Rush CM, Califano JP, Reinhart-King CA \(2012\) Cellular traction stresses increase with increasing metastatic potential. PLoS One 7\(2\):e32572:178) /S /GoTo >> endobj 491 0 obj << /Rect [ 221.022995 88.9897 236.022995 78.9897 ] /Subtype /Link /A 492 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 492 0 obj << /D (0002000676.INDD: 126. 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Jessup JM \(2013\) Cellular biotechnology operations support systems: use of NASA bioreactor to study cell cycle regulation: mechanisms of colon carcinoma metastasis in microgravity. http://www.nasa.gov/mission_pages/station/research/experiments/:221) /S /GoTo >> endobj 580 0 obj << /CropBox [ 0 0 439.369995 666.140015 ] /MediaBox [ 0 0 439.369995 666.140015 ] /Annots [ 583 0 R 585 0 R 587 0 R 589 0 R 591 0 R 593 0 R 595 0 R 597 0 R 599 0 R 601 0 R 603 0 R 605 0 R 607 0 R 609 0 R 611 0 R 613 0 R 615 0 R 617 0 R 619 0 R 621 0 R ] /Rotate 0 /Resources << /ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ] /XObject 581 0 R >> /Thumb 777 0 R /Parent 753 0 R /Contents 685 0 R /Type /Page >> endobj 581 0 obj << /X1 582 0 R >> endobj 582 0 obj << /FormType 1 /Resources << /Font 698 0 R /ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ] /ExtGState 687 0 R /ColorSpace 686 0 R >> /Matrix [ 1 0 0 1 0 0 ] /Subtype /Form /Length 3183 /Type /XObject /Filter /FlateDecode /BBox [ 0 0 439.369995 666.140015 ] >> stream xZɒ6+p"$6e< { D$FspqYϹηKH*;$2_|}xylZ*]{^pV'fObc[{)Y2Ξ^3Oߵ"?rYVp=ߖ.>=u+%j0~Z^lCe5Kڬi+cfGEjVʕ/_^nFMm#,jl/ ?kφ6yͳ~L(Ȯd۹{{k&+` ;,Yu~p*?; Cw9~ 'a p[nNBon9fC8N3 t<`-Vʯ{E".gČ@h0uρ:.XU55OʳUYhjK#H?4O3-FHg Ӹi7c_$'H>j.-4A"ֲњ԰Ո4wڲ߻Q/[pJ."?$)+,6%}ܪ*9ȼ襴ֺñʺ+ݴ*:tK\8ر^1龱+W)Ȅ6Ѵ00}Gi˽򳾷ɲ׳չ(ħLˏ,;Kڄ62#V۱6a*&x-2岲&+Ĵʢn$窆gٜ2Ȱܱ0˳ڼt¦)ӝm%҆қ\10i9=4r%.%6ԟ鍳ıժ%՘3Ƽа.V:ip: $(D2"!et&[k?+_SE;CE番ɯ49Kڊ-;bwVTsT!wh= kfr X6f9Cd~ 0 'g6Ey2Łܴ_u əUlgT@dF3X{-XCUףcR;j+Y[qP># *8_&EޘFEkq_6@\G]#- t8@ChjJFsΘSTz|IXUKH]61҅h`snҷr0;1;!J4֪-'2>D))Ѭ`04&ճ墶2贳ܽ:dƻ5q:<-F#C0Ex[[\$,h։JQiq+L4Ț5(&0۞XmQtI8MDF[:'=9n=ه<:3*0ITDMSr}w><|L[vq{ =%>(d9!ʰ~36˓=q!;ᴡ*;@]ϊ{E4ܳ08>5ڸϽ.{e<YalLs!Ʃ|us!u.!ߕ(QPKmV;eƶRk5Wə;KqOW4W6&GtG# z9˽5/HcXǎ eċ\OuS.nʵCmi答Ht ,V^W=\t C2ڡ͠Qx(FI 8-wMW@_~񊥣i܋cBTsiy2sHJI*1>٣ht,?9n~{y+qq,i zSFFW@$kwKwQ$zja31+3ȃ=/jg>!;:h(JC澹3s%1B33';Yo>}knHM"ma7m?Yww옉:O tEQ\!;x|S.k}m0[_L?g^Fo UjL$jؕe^puId-(4jʧ|\bu!md2i)PaӴ+ %sLhtj߾nžW ͟o)(2nX1r'˱w *ڌn6q"GsbI!30/Cpef1̥fco"g *MZIiwL2u@gH%)E0s< ݫhl0 wߐVű+n!= YA0YBؗ8QhEcܕKd V&NjEIXwJxFRB`x7GLk !Bkk`sqy#5/ 2sB`oK |G|`)PAD'hUGL{6MjI:#/XFlUt]XfJAYkYWg @q4R ?|{6Jp6;* ohmUn!v?=&{_F׵-'Dnu3֊&K~Q-ӱaZYA;OKWz/e+Yg6 endstream endobj 583 0 obj << /Rect [ 259.078003 592.98999 274.078003 582.98999 ] /Subtype /Link /A 584 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 584 0 obj << /D (0002000676.INDD: 151. 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Abu-Yousif AO, Rizvi I, Evans CL, Celli JP, Hasan T \(2009\) Puramatrix encapsulation of cancer cells. J Vis Exp \(34\):229) /S /GoTo >> endobj 599 0 obj << /Rect [ 177.130005 496.98999 192.130005 486.98999 ] /Subtype /Link /A 600 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 600 0 obj << /D (0002000676.INDD: 158. Martin KJ, Patrick DR, Bissell MJ, Fournier MV \(2008\) Prognostic breast cancer signature identified from 3d culture model accurately predicts clinical outcome across independent datasets. PLoS One 3\(8\):e2994:230) /S /GoTo >> endobj 601 0 obj << /Rect [ 196.899994 496.98999 211.899994 486.98999 ] /Subtype /Link /A 602 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 602 0 obj << /D (0002000676.INDD: 159. Kunz-Schughart LA, Freyer JP, Hofstaedter F, Ebner R \(2004\) The use of 3-d cultures for high-throughput screening: the multicellular spheroid model. 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Bartholoma P, Reininger-Mack A, Zhang Z, Thielecke H, Robitzki A \(2005\) A more aggressive breast cancer spheroid model coupled to an electronic capillary sensor system for a high-content screening of cytotoxic agents in cancer therapy: 3-dimens:236) /S /GoTo >> endobj 613 0 obj << /Rect [ 307.799988 316.98999 322.679993 306.98999 ] /Subtype /Link /A 614 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 614 0 obj << /D (0002000676.INDD: 163. Zhang X, Wang W, Yu W, Xie Y, Zhang X, Zhang Y, Ma X \(2005\) Development of an in vitro multicellular tumor spheroid model using microencapsulation and its application in anticancer drug screening and testing. Biotechnol Prog 21\(4\):1289 1296:237) /S /GoTo >> endobj 615 0 obj << /Rect [ 57.148201 292.98999 72.028198 282.98999 ] /Subtype /Link /A 616 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 616 0 obj << /D (0002000676.INDD: 161. Teicher BA \(2009\) Acute and chronic in vivo therapeutic resistance. Biochem Pharmacol 77\(11\):1665 1673:238) /S /GoTo >> endobj 617 0 obj << /Rect [ 83.918701 220.990005 93.838699 210.990005 ] /Subtype /Link /A 618 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 618 0 obj << /D (0002000676.INDD: 82. Kleinman HK, Martin GR \(2005\) Matrigel: Basement membrane matrix with biological activity. In: Seminars in cancer biology. Elsevier, 15\(5\):378 386:239) /S /GoTo >> endobj 619 0 obj << /Rect [ 233.789993 196.990005 248.669998 186.990005 ] /Subtype /Link /A 620 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 620 0 obj << /D (0002000676.INDD: 164. Schmeichel KL, Bissell MJ \(2003\) Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci 116\(12\):2377 2388:240) /S /GoTo >> endobj 621 0 obj << /Rect [ 269.013 136.990005 283.893005 126.989998 ] /Subtype /Link /A 622 0 R /Border [ 0 0 0 ] /F 4 /BS 697 0 R /H /N /Type /Annot >> endobj 622 0 obj << /D (0002000676.INDD: 165. 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