Research Information
Research Interests
I have over 15 years of experience in the fields of cardiovascular engineering, cardiac electrophysiology, and medical devices. I have been interested in the mechanism of atrial fibrillation and signal processing. I have researched two canine models (sterile pericarditis and vagal nerve stimulation atrial fibrillation) and human persistent or postoperative atrial fibrillation to understand the mechanism of atrial fibrillation. I have developed, improved, and applied several signal processing analysis algorithms in both time and frequency domains to characterize atrial electrograms of atrial fibrillation during real-time data acquisition. I have applied these analysis algorithms to clinical studies. Using high density mapping with these algorithms, we can understand the mechanism of atrial fibrillation and apply real-time analysis algorithms to improve surgical or catheter ablation therapies. More recently, I have partnered with a manufacturing company for developing a smart mapping catheter (catheter + analysis algorithm).
Publications
- Lee S., Khrestian CM, Laurita D, Juzbasich D, Wallick D, Waldo AL. Pacing and Clinical Electrophysiology 2023; 1 - 7.
- Lee S., Khrestian CM, Sahadevan J, Waldo AL. Journal of Clinical Medicine. 2022;11(19), 5807.
- Lee S, Vitebskiy S, Goldstein RN, Khrestian CM and Waldo AL. Heart Rhythm O2. 2022;3:91-96.
- Schotten U., Lee S., Zeemering S., Waldo AL. Europace, 2021; 23(Supplement_2): ii9-ii13.
- Lee S., Khrestian CM., Sahadevan J., Markowitz A., Waldo AL. JACC Clin Electrophysiol. 2021;7:909-919.
- Lee S, Khrestian CM, Sahadevan J, Waldo AL. Heart Rhythm 2020. PMID: 32585192
- Lee S., Khrestian A., Waldo AL., Khrestian CM., Markowitz A., Sahadevan J. Journal of the American Heart Association. 2019;8:e011401 PMCID: PMC6585332
- Lee S., Sahadevan J., Khrestian C., Markowitz A., Waldo A.L. Journal of American Heart Association 2017;6(3):e005274. PMCID:PMC5524032
- Lee S., Sahadevan J., Khrestian C., Cakulev I., Markowitz A., Waldo A.L. Circulation 2015;132:2108-2117. PMCID: PMC4666790
- Sadrpour S.A., Srinivasan D., Bhimani A.A., Lee S., Ryu K., Cakulev I., Khrestian C.M., Markowitz A., Waldo A.L., Sahadevan J. Europace 2015;17(12):1834-9. PMID: 25911349
- Sadrpour S.A., Serhal M., Khrestian C., Lee S., Fields T., Dittrich H., Waldo A.L. J Cardiovasc Pharmacol 2015;65:494-9.
- Bhimani A.A., Yasuda T., Sadrpour S.A., Khrestian C.M., Lee S., Zeng D., Belardinelli L., Waldo A.L. Heart Rhythm, 2014;11:1592-99.
- Lee S, Sahadevan J, Khrestian C, Durand D, Waldo A. Journal of Cardiovascular Electrophysiology 2013;24:328-335. PMID: 23210508
- Lee S, Ryu K, Waldo A, Khrestian C, Durand D, Sahadevan J. Journal of Cardiovascular Electrophysiology. 2013;24:199-206. PMID: 23140386